Xin Lili, Jiang Miao, Su Guangbao, Xie Miao, Chen Hui, Liu Xiao, Xu Muge, Zhang Geng, Gong Jiening
Basic Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing City, Jiangsu Province, China.
Medicine (Baltimore). 2018 Sep;97(37):e11876. doi: 10.1097/MD.0000000000011876.
Although many studies have investigated the association of single nucleotide polymorphisms (SNPs) in transforming growth factor beta1 (TGF-β1) gene with pulmonary fibrosis (PF), but their association is still controversial. To clarify this, we performed a meta-analysis.Studies related to TGF-β1 and PF were retrieved from PubMed, Medline, Embase, Scopus, and Wanfang (up to November 30, 2017). We targeted TGF-β1 SNPs that have been reported by ≥3 studies to be included in the current meta-analysis, resulting in only 1 final SNP (rs1800470). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (T vs C), homozygote comparison (TT vs CC), dominant (TT vs TC + CC), recessive (TT + TC vs CC) to evaluate the strength of the associations.A total of 7 case-control studies were included in this meta-analysis. Overall, no significant association between TGF-β1 rs1800470 and PF was found (T vs C: OR [95% CI] = 0.96 [0.80, 1.15]; TT vs CC: 0.87 [0.61, 1.22]; TT vs TC + CC: 0.80 [0.62, 1.04]; TT + TC vs CC: 1.13 [0.83, 1.54]). In subgroup analyses by ethnicity or original disease, no statistically significant association between TGF-β1 rs1800470 polymorphisms and PF was demonstrated.This meta-analysis revealed that TGF-β1 rs1800470 polymorphism was not associated with susceptibility to PF development.
尽管许多研究调查了转化生长因子β1（TGF-β1）基因中的单核苷酸多态性（SNP）与肺纤维化（PF）的关联，但它们之间的关联仍存在争议。为了阐明这一点，我们进行了一项荟萃分析。从PubMed、Medline、Embase、Scopus和万方数据库（截至2017年11月30日）检索了与TGF-β1和PF相关的研究。我们将≥3项研究报道的TGF-β1 SNP作为纳入本次荟萃分析的目标，最终仅得到1个SNP（rs1800470）。在等位基因比较（T对C）、纯合子比较（TT对CC）、显性模型（TT对TC+CC）、隐性模型（TT+TC对CC）中估计比值比（OR）和95%置信区间（CI），以评估关联强度。本荟萃分析共纳入7项病例对照研究。总体而言，未发现TGF-β1 rs1800470与PF之间存在显著关联（T对C：OR[95%CI]=0.96[0.80，1.15]；TT对CC：0.87[0.61，1.22]；TT对TC+CC：0.80[0.62，1.04]；TT+TC对CC：1.13[0.83，1.54]）。在按种族或原发病进行的亚组分析中，未显示TGF-β1 rs1800470多态性与PF之间存在统计学显著关联。这项荟萃分析表明，TGF-β1 rs1800470多态性与PF发生的易感性无关。
