转化生长因子-β1 的 C509T、T869C、G915C 基因多态性与系统性红斑狼疮易感性的关系：Meta 分析。
The association between C509T, T869C, G915C gene polymorphisms of transforming growth factor-β1 and systemic lupus erythematosus risk: A meta-analysis.
机构信息
Department of Infectious Diseases, South Branch of Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Department of Rheumatology and Immunology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
出版信息
Medicine (Baltimore). 2023 Mar 17;102(11):e33321. doi: 10.1097/MD.0000000000033321.
BACKGROUND
The relationship between transforming growth factor-β1 (TGF- β1) gene polymorphisms and systemic lupus erythematosus (SLE) has been reported in many studies, but there were still controversies with regard to their conclusions.
METHODS
Relevant documents were retrieved from 5 electronic databases such as PubMed, Embase, Cochrane Library, Wanfang, and China national knowledge infrastructure. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to assess the relationship between TGF-β1 genetic variation and SLE.
RESULTS
The present meta-analysis included 12 case-control studies with 1308 SLE patients and 1714 healthy controls. The results of the combined analyses showed that TGF-β1 C509T polymorphism showed no association with SLE risk (TC vs CC: OR = 1.16, 95% CI = 0.91-1.48, PHeterogeneity (PH) = 0.579; TT vs CC: OR = 1.15, 95% CI = 0.63-2.09, PH = 0.003; T vs C: OR = 1.08, 95% CI = 0.8-1.45, PH = 0.003; TC/TT vs CC: OR = 1.17, 95% CI = 0.93-1.46, PH = 0.133; and TT vs TC/CC: OR = 1.06, 95% CI = 0.64-1.76, PH = 0.004). TGF-β1 G915C and T869C polymorphisms were not linked with SLE risk. Moreover, subgroup analysis stratified by ethnicity and Hardy-Weinberg equilibrium revealed no significant correlation of TGF-β1 T869C, C509T, G915C polymorphisms with SLE risk.
CONCLUSION
TGF-β1 T869C, C509T, G915C polymorphisms might not be associated with the development of SLE.
背景
转化生长因子-β1（TGF-β1）基因多态性与系统性红斑狼疮（SLE）的关系在许多研究中已有报道，但结论仍存在争议。
方法
从 PubMed、Embase、Cochrane Library、万方和中国知识基础设施等 5 个电子数据库中检索相关文献。使用比值比（OR）及其相应的 95％置信区间（CI）来评估 TGF-β1 遗传变异与 SLE 之间的关系。
结果
本荟萃分析纳入了 12 项病例对照研究，共包括 1308 例 SLE 患者和 1714 名健康对照。合并分析结果显示，TGF-β1 C509T 多态性与 SLE 发病风险无关（TC 与 CC：OR=1.16，95％CI=0.91-1.48，PHeterogeneity（PH）=0.579；TT 与 CC：OR=1.15，95％CI=0.63-2.09，PH=0.003；T 与 C：OR=1.08，95％CI=0.8-1.45，PH=0.003；TC/TT 与 CC：OR=1.17，95％CI=0.93-1.46，PH=0.133；TT 与 TC/CC：OR=1.06，95％CI=0.64-1.76，PH=0.004）。TGF-β1 G915C 和 T869C 多态性与 SLE 发病风险无关。此外，按种族和 Hardy-Weinberg 平衡分层的亚组分析显示，TGF-β1 T869C、C509T、G915C 多态性与 SLE 发病风险无显著相关性。
结论
TGF-β1 T869C、C509T、G915C 多态性可能与 SLE 的发生发展无关。
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