Li Yabin, Luo Xianggui, Wan Miao, Li Jiao, Wang Hongxia, Wei Dang, Feng Haixia
Department of Neurological Rehabilitation, Rehabilitation Central Hospital of Gansu Province The First Clinical Medical College of Lanzhou University, Lanzhou, China Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
Medicine (Baltimore). 2018 Sep;97(37):e12321. doi: 10.1097/MD.0000000000012321.
Traumatic brain injury is a leading cause of death and disability worldwide. The survivors usually suffer from disorders of consciousness, especially coma state and persistent vegetative state. For these patients, there is no standard treatment for them, but non-invasive brain stimulations are considered as relatively more acceptable treatments. However, the knowledge regarding the relative effectiveness and the rank of the effectiveness of the non-invasive brain stimulations is limited. Thus, in this study, we aim to conduct a systematic review and network meta-analysis to evaluate the effect of non-invasive train stimulations on arousal and alertness in patients in a coma or persistent vegetative state after traumatic brain injury.
A comprehensive search strategy will be performed in the relevant databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wan Fang Data). The random or quasi-random controlled trails focusing on the effectiveness of the non-invasive brain stimulations will be included. The risk of bias for the included studies will be appraised using the Cochrane collaboration tool for assessing risk of bias. The standard pairwise meta-analysis and a Bayesian network meta-analysis will be conducted.
This research is a systematic review and network meta-analysis. Thus, there is no requirement of ethical approval and patient informed consent.
CRD42018104945.
创伤性脑损伤是全球范围内死亡和残疾的主要原因。幸存者通常患有意识障碍，尤其是昏迷状态和持续性植物状态。对于这些患者，尚无标准治疗方法，但非侵入性脑刺激被认为是相对更可接受的治疗方法。然而，关于非侵入性脑刺激的相对有效性和有效性排名的知识有限。因此，在本研究中，我们旨在进行系统评价和网状Meta分析，以评估非侵入性脑刺激对创伤性脑损伤后昏迷或持续性植物状态患者觉醒和警觉性的影响。
将在相关数据库（MEDLINE、EMBASE、Cochrane对照试验中央登记库、世界卫生组织（WHO）国际临床试验注册平台（ICTRP）、中国生物医学文献数据库、中国知网、万方数据）中执行全面的检索策略。将纳入关注非侵入性脑刺激有效性的随机或准随机对照试验。将使用Cochrane协作工具评估纳入研究的偏倚风险。将进行标准的成对Meta分析和贝叶斯网状Meta分析。
本研究是一项系统评价和网状Meta分析。因此，无需伦理批准和患者知情同意。
PROSPERO注册号：CRD42018104945。
