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[可的松抗性胸腺细胞对近交系小鼠内源性集落形成的影响]

[Effect of cortisone-resistant thymocytes on endogenous colony formation in inbred mice].

作者信息

Semenkov V F, Kostiukov A A

出版信息

Biull Eksp Biol Med. 1977 Jul;84(7):66-8.

PMID:302131
Abstract

Endogenous colonies in the spleen of sublethally irradiated (CBA X C57BL/6) E1 hybrid mice were recorded after the injection of thymocytes and the lymph node cells from the hydrocortisone-treated and intact CBA mice. Cortisone-resistant thymocytes failed to suppress the endogenous colony formation, whereas the lymph node cells produced a distinct suppressive effect on the endogenous colonies. After the injection of cortisone-resistant thymocytes the number of colonies in the spleen of individual recipients was double that in control irradiated hybrids.

摘要

在给经亚致死剂量照射的(CBA×C57BL/6)E1杂交小鼠注射来自氢化可的松处理的和未处理的CBA小鼠的胸腺细胞及淋巴结细胞后,记录其脾脏中的内源性集落。抗可的松胸腺细胞未能抑制内源性集落形成,而淋巴结细胞对内源性集落产生了明显的抑制作用。注射抗可的松胸腺细胞后,个体受者脾脏中的集落数量是对照照射杂交小鼠的两倍。

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