Colli A, Buccino G, Cocciolo M, Parravicini R, Mariani F, Scaltrini G
Cancer. 1986 Dec 1;58(11):2489-93. doi: 10.1002/1097-0142(19861201)58:11<2489::aid-cncr2820581123>3.0.co;2-8.
To evaluate the diagnostic accuracy of fibronectin levels in ascites to differentiate malignant from non-malignant ascites, the authors studied 30 patients with sterile uncomplicated ascites in chronic liver disease, 18 patients with malignant ascites and four patients with spontaneous bacterial peritonitis. Fibronectin concentration was significantly higher in malignant ascites than in sterile ascites (P less than 0.001). High values (greater than 85 mg/l) were found in four of six cases of hepatocellular carcinoma in liver cirrhosis with negative cytologic examination, and in six of seven peritoneal carcinomatoses. Low values (less than 85 mg/l) were found in four patients with liver metastases and in one patient with intrahepatic biliary duct carcinoma in cirrhosis. In four patients with infected ascites, the fibronectin level was low. Among all other parameters (total protein concentration, lactate dehydrogenase, gamma-glutamyl-transpeptidase, pH, amylase, triglycerides, leukocyte count, and cytologic examination), fibronectin yielded the best degree of discrimination (diagnostic accuracy, 79%).
为评估腹水纤连蛋白水平对鉴别恶性腹水与非恶性腹水的诊断准确性，作者研究了30例慢性肝病无菌性单纯腹水患者、18例恶性腹水患者和4例自发性细菌性腹膜炎患者。恶性腹水中纤连蛋白浓度显著高于无菌性腹水（P＜0.001）。在肝硬化肝细胞癌6例细胞学检查阴性病例中有4例、7例腹膜癌转移病例中有6例纤连蛋白值较高（＞85mg/l）。在4例肝转移患者和1例肝硬化肝内胆管癌患者中纤连蛋白值较低（＜85mg/l）。4例感染性腹水患者的纤连蛋白水平较低。在所有其他参数（总蛋白浓度、乳酸脱氢酶、γ-谷氨酰转肽酶、pH值、淀粉酶、甘油三酯、白细胞计数和细胞学检查）中，纤连蛋白的鉴别程度最佳（诊断准确性为79%）。
