Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA.
Trends Immunol. 2018 Oct;39(10):830-847. doi: 10.1016/j.it.2018.08.006. Epub 2018 Sep 10.
Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear. Recent findings regarding the role of Wnt ligands and Wnt signaling in immune cells and their immunomodulatory mechanisms suggest that Wnt ligands and signaling are significant in regulating immune responses. We introduce recent key findings and future perspectives on Wnt ligands and their signaling pathways in immune cells as well as the immunological roles and functions of Wnt antagonists.
细胞分化、增殖和死亡对于免疫稳态至关重要。Wnt 信号在跨越物种的过程中发挥着重要作用。过去已经研究了 Wnt 信号蛋白和 Wnt 配体的作用，但这些途径在免疫反应中的上下文相关机制和功能仍不清楚。最近关于 Wnt 配体和 Wnt 信号在免疫细胞中的作用及其免疫调节机制的发现表明，Wnt 配体和信号在调节免疫反应中具有重要意义。我们介绍了 Wnt 配体及其信号通路在免疫细胞中的最新关键发现和未来展望，以及 Wnt 拮抗剂的免疫学作用和功能。
