Senior Research Scientist, Department of Pharmacology, School of Medicine, Yale University, New Haven, USA.
PhD, Department of Orthodontics, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Biomed Pharmacother. 2017 Sep;93:359-369. doi: 10.1016/j.biopha.2017.06.061. Epub 2017 Jun 24.
Wnt signaling regulates many aspects of vertebrate development. Its dysregulation causes developmental defects and diseases including cancer. The signaling can be categorized in two pathways: canonical and noncanonical. Canonical pathway plays a key role in regulating proliferation and differentiation of cells whilst noncanonical Wnt signaling mainly controls cellular polarity and motility. During development, noncanonical Wnt signaling is required for tissue formation. Recent studies have shown that noncanonical Wnt signaling is involved in adult tissue development and cancer progression. In this review, we try to describe and discuss the mechanisms behind the biological effects of noncanonical Wnt signaling, diseases caused by its dysregulation, and implications in adult tissue development biology.
Wnt 信号通路调节脊椎动物发育的许多方面。其失调会导致发育缺陷和疾病，包括癌症。该信号通路可分为两条通路：经典途径和非经典途径。经典途径在调节细胞的增殖和分化中起着关键作用，而非经典 Wnt 信号通路主要控制细胞极性和运动。在发育过程中，非经典 Wnt 信号通路对于组织形成是必需的。最近的研究表明，非经典 Wnt 信号通路参与了成人组织发育和癌症的进展。在这篇综述中，我们试图描述和讨论非经典 Wnt 信号通路的生物学效应背后的机制、其失调引起的疾病，以及在成人组织发育生物学中的意义。
