Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Drug Discov Today. 2019 Jan;24(1):279-284. doi: 10.1016/j.drudis.2018.09.004. Epub 2018 Sep 10.
Corticotropin-releasing factor (CRF) and the three homolog neuropeptides, urocortin (UCN) 1, 2 and 3, are the major neuroendocrine factors implicated in the response of the body to stress. Recent evidence suggests that UCNs have a significant role in the pathogenesis and management of cardiovascular disease, such as congestive heart failure, ischemic heart disease, and hypertension. These data led to the initiation of clinical trials testing a possible role of UCNs in the diagnosis and therapy of cardiovascular disease, with encouraging results. Here, we summarize the available literature concerning the role of UCNs in the cardiovascular system, focusing on the emerging data creating a potential for clinical applications.
促肾上腺皮质素释放因子（CRF）和三种同源神经肽，尿皮质素（UCN）1、2 和 3，是主要的神经内分泌因子，参与了身体对压力的反应。最近的证据表明，UCNs 在心血管疾病的发病机制和治疗中具有重要作用，如充血性心力衰竭、缺血性心脏病和高血压。这些数据促使人们开始进行临床试验，以测试 UCNs 在心血管疾病的诊断和治疗中的可能作用，结果令人鼓舞。在这里，我们总结了有关 UCNs 在心血管系统中的作用的现有文献，重点介绍了正在出现的具有潜在临床应用前景的数据。
