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趋化因子CCL7与ABCE1在非小细胞肺癌中的表达及相关性

The expression and correlation between chemokine CCL7 and ABCE1 in non-small cell lung cancer.

作者信息

Wu Zhuo, Tian Ye, Yu Qian, Li Hongyuan, Tian Zhiqiang, Jiang Hongfang, Tian Dali, Yang Xueying

机构信息

Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.

Department of Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China.

出版信息

Exp Ther Med. 2018 Oct;16(4):3004-3010. doi: 10.3892/etm.2018.6568. Epub 2018 Aug 2.

DOI:10.3892/etm.2018.6568
PMID:30214518
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6125957/
Abstract

Lung cancer is a malignant disease, and has the highest incidence and mortality worldwide. Lung cancer is also a popular subject in the field of cancer research. The molecular mechanisms of lung cancer development, invasion and metastasis need to be determined to prolong survival times and improve the quality of life. Recent studies have demonstrated that ATP-binding cassette sub-family E member 1 (ABCE1) is one of the factors that contributes to the development and metastasis of lung cancer, but the specific mechanism of this phenomenon remains unclear. A polymerase chain reaction microarray was used in the present study to screen for chemokine (C-C motif) ligand 7 (CCL7) expression in cell lines that highly expressed ABCE1, and the results showed that CCL7 was highly expressed in H1299 cells (P<0.01). The expression of CCL7 and ABCE1 in lung cancer tissues obtained from 30 patients with non-small cell lung cancer (NSCLC) was higher than that in adjacent normal lung tissues (P<0.01), and a positive correlation between the expression levels of the two genes in NSCLC was observed. These findings indicate that ABCE1 is involved in the development and progression of lung cancer through the CCL7 signaling pathway.

摘要

肺癌是一种恶性疾病，在全球范围内发病率和死亡率最高。肺癌也是癌症研究领域的热门课题。为了延长生存期并提高生活质量，需要确定肺癌发生、侵袭和转移的分子机制。最近的研究表明，ATP结合盒亚家族E成员1（ABCE1）是导致肺癌发生和转移的因素之一，但这一现象的具体机制仍不清楚。本研究使用聚合酶链反应微阵列筛选高表达ABCE1的细胞系中趋化因子（C-C基序）配体7（CCL7）的表达，结果显示CCL7在H1299细胞中高表达（P<0.01）。30例非小细胞肺癌（NSCLC）患者的肺癌组织中CCL7和ABCE1的表达高于相邻正常肺组织（P<0.01），且在NSCLC中观察到这两个基因表达水平呈正相关。这些发现表明，ABCE1通过CCL7信号通路参与肺癌的发生和进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/32c42b46b44c/etm-16-04-3004-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/f4e8d0e76787/etm-16-04-3004-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/1c77ad05b052/etm-16-04-3004-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/f6400178fcf1/etm-16-04-3004-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/5540839bd1d3/etm-16-04-3004-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/32c42b46b44c/etm-16-04-3004-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/f4e8d0e76787/etm-16-04-3004-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/1c77ad05b052/etm-16-04-3004-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/f6400178fcf1/etm-16-04-3004-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/5540839bd1d3/etm-16-04-3004-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c500/6125957/32c42b46b44c/etm-16-04-3004-g04.jpg

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