新型细菌拓扑异构酶抑制剂：降低hERG毒性的挑战与前景 - Suppr

Novel bacterial topoisomerase inhibitors: challenges and perspectives in reducing hERG toxicity.

作者信息

Kolarič Anja, Minovski Nikola

机构信息

Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia.

出版信息

Future Med Chem. 2018 Oct 1;10(19):2241-2244. doi: 10.4155/fmc-2018-0272. Epub 2018 Sep 14.

DOI:10.4155/fmc-2018-0272

PMID:30215281

Abstract

摘要

相似文献

Novel bacterial topoisomerase inhibitors: challenges and perspectives in reducing hERG toxicity.

Future Med Chem. 2018 Oct 1;10(19):2241-2244. doi: 10.4155/fmc-2018-0272. Epub 2018 Sep 14.

1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.

ACS Infect Dis. 2019 Jul 12;5(7):1115-1128. doi: 10.1021/acsinfecdis.8b00375. Epub 2019 May 9.

Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3636-43. doi: 10.1016/j.bmcl.2015.06.057. Epub 2015 Jun 19.

Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs).

J Med Chem. 2020 Jun 11;63(11):5664-5674. doi: 10.1021/acs.jmedchem.9b01738. Epub 2020 Feb 17.

Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3353-3358. doi: 10.1016/j.bmcl.2017.06.009. Epub 2017 Jun 3.

Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2409-15. doi: 10.1016/j.bmcl.2015.04.002. Epub 2015 Apr 7.

Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3630-5. doi: 10.1016/j.bmcl.2015.06.061. Epub 2015 Jun 23.

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2473-8. doi: 10.1016/j.bmcl.2015.04.063. Epub 2015 Apr 28.

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.

J Med Chem. 2013 Sep 26;56(18):7396-415. doi: 10.1021/jm400963y. Epub 2013 Sep 11.

Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.

Int J Mol Sci. 2018 Feb 3;19(2):453. doi: 10.3390/ijms19020453.

引用本文的文献

Structural and Mechanistic Insights into Atypical Bacterial Topoisomerase Inhibitors.

ACS Med Chem Lett. 2025 Apr 1;16(4):660-667. doi: 10.1021/acsmedchemlett.5c00060. eCollection 2025 Apr 10.

Global health perspectives on antibacterial drug discovery and the preclinical pipeline.

Nat Rev Microbiol. 2025 Mar 27. doi: 10.1038/s41579-025-01167-w.

hERGAT: predicting hERG blockers using graph attention mechanism through atom- and molecule-level interaction analyses.

J Cheminform. 2025 Jan 28;17(1):11. doi: 10.1186/s13321-025-00957-x.

How Do Gepotidacin and Zoliflodacin Stabilize DNA Cleavage Complexes with Bacterial Type IIA Topoisomerases? 1. Experimental Definition of Metal Binding Sites.

Int J Mol Sci. 2024 Oct 30;25(21):11688. doi: 10.3390/ijms252111688.

Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria.

Nat Chem. 2024 Sep;16(9):1462-1472. doi: 10.1038/s41557-024-01516-x. Epub 2024 Jun 19.

Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance.

ACS Infect Dis. 2024 Apr 12;10(4):1097-1115. doi: 10.1021/acsinfecdis.4c00128. Epub 2024 Apr 2.

Novel Indane-Containing NBTIs with Potent Anti-Gram-Negative Activity and Minimal hERG Inhibition.

ACS Med Chem Lett. 2023 Nov 10;14(12):1791-1799. doi: 10.1021/acsmedchemlett.3c00422. eCollection 2023 Dec 14.

Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs.

Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0048223. doi: 10.1128/aac.00482-23. Epub 2023 Sep 19.

Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.

ACS Med Chem Lett. 2023 Jun 22;14(7):993-998. doi: 10.1021/acsmedchemlett.3c00187. eCollection 2023 Jul 13.

1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.

ACS Med Chem Lett. 2022 May 9;13(6):955-963. doi: 10.1021/acsmedchemlett.2c00111. eCollection 2022 Jun 9.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Novel bacterial topoisomerase inhibitors: challenges and perspectives in reducing hERG toxicity.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献