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Pegylated Naloxone in the Treatment of Persistent Opioid-Induced Constipation in Patients with Hematological Malignancies.

作者信息

Brunetti Gregorio Antonio, Palumbo Giovanna, Annechini Giorgia, Santopietro Michelina, Tendas Andrea, Niscola Pasquale, Cartoni Claudio

机构信息

Department of Cellular Biotechnology and Hematology, University La Sapienza of Rome, Rome, Italy.

Hematology Unit, S.Eugenio Hospital, Rome, Italy.

出版信息

Cardiovasc Hematol Agents Med Chem. 2018;16(1):3-4. doi: 10.2174/187152571601180910093543.

DOI:10.2174/187152571601180910093543
PMID:30215327
Abstract
摘要

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Pegylated Naloxone in the Treatment of Persistent Opioid-Induced Constipation in Patients with Hematological Malignancies.聚乙二醇化纳洛酮治疗血液系统恶性肿瘤患者持续性阿片类药物所致便秘
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[Treatment of persistent opioid-induced constipation in patients with hematological malignancies: case report].
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New Formulation of Sustained Release Naloxone Can Reverse Opioid Induced Constipation Without Compromising the Desired Opioid Effects.新型缓释纳洛酮制剂可逆转阿片类药物引起的便秘,且不影响阿片类药物的预期效果。
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[Quality of life suffers much in constipation. Plea for an intelligent pain therapy].便秘会严重影响生活质量。呼吁采用明智的疼痛治疗方法。
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▼Naloxegol for opioid-induced constipation.▼纳洛西醇用于治疗阿片类药物引起的便秘。
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One-year efficacy and safety of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: KYONAL study.癌症患者中阿片类药物诱导性便秘相关症状和生活质量的纳洛酮治疗 1 年的疗效和安全性:KYONAL 研究。
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