Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Ann N Y Acad Sci. 2018 Dec;1433(1):53-60. doi: 10.1111/nyas.13970. Epub 2018 Sep 14.
Staphylococcal nuclease domain-containing 1 (SND1) expression is crucial for breast cancer metastasis; however, the clinical implications of SND1 expression in breast cancer remain unclear. This study investigated the relationship of SND1 protein expression both with metastasis and the prognoses of 144 breast cancer patients over a 10-year follow-up. Chi-square tests revealed that the percentages of positive SND1 expression in breast cancer tumors were significantly associated with larger tumor size (>2 cm, P = 0.043), higher clinical TNM stage (P = 0.003), and positive lymph node metastasis (P = 0.001). Breast cancer patients with positive SND1 expression had a significantly shorter overall survival and disease-free survival than those with negative SND1 expression (P < 0.01). Multiple Cox regression analysis indicated that SND1 expression is an independent risk factor for shorter disease-free survival (hazard ratio = 1.97, P = 0.014). The percentages of SND1 expression in metastatic breast cancers were significantly higher than that in primary tumors in 30 patients with advanced breast cancer (P = 0.016). Therefore, SND1 protein expression is significantly associated with breast cancer metastasis and may serve as a biomarker for prognosis of breast cancer patients.
富含核小体酶结构域蛋白 1（SND1）的表达对乳腺癌转移至关重要；然而，SND1 在乳腺癌中的表达与临床意义仍不清楚。本研究通过对 144 例乳腺癌患者进行长达 10 年的随访，研究了 SND1 蛋白表达与转移和预后的关系。卡方检验显示，乳腺癌肿瘤中 SND1 阳性表达的百分比与肿瘤较大（>2cm，P=0.043）、临床 TNM 分期较高（P=0.003）和阳性淋巴结转移（P=0.001）显著相关。SND1 阳性表达的乳腺癌患者的总生存期和无病生存期明显短于 SND1 阴性表达的患者（P<0.01）。多因素 Cox 回归分析表明，SND1 表达是无病生存期较短的独立危险因素（风险比=1.97，P=0.014）。在 30 例晚期乳腺癌患者中，转移性乳腺癌中 SND1 表达的百分比明显高于原发性肿瘤（P=0.016）。因此，SND1 蛋白表达与乳腺癌转移显著相关，可能成为预测乳腺癌患者预后的生物标志物。
