Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Int J Med Sci. 2021 Jan 1;18(1):239-244. doi: 10.7150/ijms.43100. eCollection 2021.
The role of heat shock protein 70 (HSC70) in the progression of clear cell renal cell carcinoma (ccRCC) is unclear. This study explored the effect of the HSC70 on the survival of ccRCC patients. Immunohistochemical analysis was performed to determine HSC70 expression in samples obtained from 121 ccRCC patients with at least 5 years of follow-up. We also analyzed the association between HSC70 expression and clinicopathological characteristics. Furthermore, the association of overall survival (OS) with HSC70 expression was analyzed using Kaplan-Meier curves. Finally, we used the Oncomine and CCLE databases to determine the effects of HSC70 mRNA expression on ccRCC. HSC70 expression was associated with distant metastasis and death of ccRCC patients. HSC70 was expressed in the nucleus and/or cytoplasm of ccRCC cells. The incidence of distant organ metastasis and death was higher in patients with HSC70 expression than in those without it. Survival analysis revealed that patients with HSC70 expression had significantly shorter OS. Oncomine analyses also showed that the HSC70 mRNA was significantly upregulated in ccRCC tissues. HSC70 expression was related to adverse prognosis, and patients with HSC70 expression had a worse prognosis than those without HSC70 expression. may thus serve as a potential therapeutic target for ccRCC.
热休克蛋白 70（HSC70）在透明细胞肾细胞癌（ccRCC）进展中的作用尚不清楚。本研究探讨了 HSC70 对 ccRCC 患者生存的影响。 对 121 例至少随访 5 年的 ccRCC 患者的样本进行免疫组织化学分析，以确定 HSC70 的表达。我们还分析了 HSC70 表达与临床病理特征之间的关系。此外，使用 Kaplan-Meier 曲线分析 HSC70 表达与总生存（OS）的关系。最后，我们使用 Oncomine 和 CCLE 数据库来确定 HSC70 mRNA 表达对 ccRCC 的影响。 HSC70 表达与 ccRCC 患者的远处转移和死亡有关。HSC70 在 ccRCC 细胞的核和/或细胞质中表达。与无 HSC70 表达的患者相比，HSC70 表达的患者发生远处器官转移和死亡的发生率更高。生存分析显示，HSC70 表达的患者 OS 明显缩短。Oncomine 分析还显示 HSC70 mRNA 在 ccRCC 组织中显著上调。 HSC70 表达与不良预后相关，HSC70 表达的患者预后较无 HSC70 表达的患者差。 可能因此成为 ccRCC 的潜在治疗靶点。
