通过交换标记对（E）-5-（2-碘乙烯基）-2'-脱氧尿苷（IVDU）进行简单的定量放射性碘化。
Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by exchange labelling.
作者信息
Verbruggen A, Julien C, De Clercq E, De Roo M
出版信息
Int J Rad Appl Instrum A. 1986;37(4):355-7. doi: 10.1016/0883-2889(86)90126-7.
PMID:3021658
Abstract
The synthesis of [125I]-(E)-5-(2-iodovinyl)-2'-deoxyuridine [( 125I]IVDU) by a halogen isotope exchange reaction has been monitored in various reaction conditions. Quantitative incorporation of radioiodine into IVDU was obtained within 20 min by a simple and safe method that is suitable for application in any nuclear medicine laboratory. The radiolabelled antiviral agent can be used without further purification.
摘要
通过卤素同位素交换反应合成[125I]-(E)-5-(2-碘乙烯基)-2'-脱氧尿苷([125I]IVDU)的过程已在各种反应条件下进行了监测。通过一种简单且安全的方法，在20分钟内即可实现放射性碘向IVDU的定量掺入，该方法适用于任何核医学实验室。这种放射性标记的抗病毒剂无需进一步纯化即可使用。
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