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1
Quantitative uptake studies of 131I-labeled (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells in vitro.体外单纯疱疹病毒感染细胞中131I标记的（E）-5-（2-碘乙烯基）-2'-脱氧尿苷的定量摄取研究
Antimicrob Agents Chemother. 1984 Apr;25(4):476-8. doi: 10.1128/AAC.25.4.476.
2
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.胸苷酸合成酶是（E）-5-（2-溴乙烯基）-2'-脱氧尿苷对用1型或2型单纯疱疹病毒胸苷激酶基因转化的小鼠乳腺癌（FM3A）细胞的细胞生长抑制活性的主要靶酶。
Mol Pharmacol. 1987 Sep;32(3):410-6.
3
Differential metabolism of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by equine herpesvirus type 1- and herpes simplex virus-infected cells.
Antiviral Res. 1987 Aug;8(1):41-51. doi: 10.1016/0166-3542(87)90086-6.
4
Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.E-5-(2-[¹³¹I]碘乙烯基)-2'-脱氧尿苷在犬体内的药代动力学和代谢
Antimicrob Agents Chemother. 1986 Feb;29(2):320-4. doi: 10.1128/AAC.29.2.320.
5
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷衍生物对用1型单纯疱疹病毒胸苷激酶基因转化的小鼠乳腺癌（FM3A）细胞具有高度选择性的细胞生长抑制活性。
Mol Pharmacol. 1985 Dec;28(6):581-7.
6
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.用单纯疱疹病毒1型胸苷激酶基因转导的肿瘤细胞中（E）-5-（2-[¹²⁵I]碘乙烯基）-2'-脱氧尿苷2'-取代类似物的合成及细胞摄取。作为监测基因治疗的探针的评估。
J Med Chem. 1997 Jul 4;40(14):2184-90. doi: 10.1021/jm9606406.
7
Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.（E）-5-（2-卤代乙烯基）-2'-脱氧尿苷碳环类似物的选择性抗疱疹活性：依赖于病毒胸苷激酶的特异性磷酸化作用。
Biochem Biophys Res Commun. 1985 Jan 16;126(1):397-403. doi: 10.1016/0006-291x(85)90619-9.
8
Incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine into deoxyribonucleic acids of varicella-zoster virus (TK+ and TK- strains)-infected cells.（E）-5-（2-碘乙烯基）-2'-脱氧尿苷掺入水痘带状疱疹病毒（TK+和TK-毒株）感染细胞的脱氧核糖核酸中。
Mol Pharmacol. 1987 May;31(5):493-9.
9
Role of the incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine and its carbocyclic analogue into DNA of herpes simplex virus type 1-infected cells in the antiviral effects of these compounds.（E）-5-（2-碘乙烯基）-2'-脱氧尿苷及其碳环类似物掺入单纯疱疹病毒1型感染细胞的DNA在这些化合物抗病毒作用中的作用。
Mol Pharmacol. 1990 Mar;37(3):402-7.
10
Metabolism of the carbocyclic analogue of (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells. Incorporation of C-IVDU into DNA.（E）-5-（2-碘乙烯基）-2'-脱氧尿苷碳环类似物在单纯疱疹病毒感染细胞中的代谢。碳环-碘脱氧尿苷掺入DNA。
J Biol Chem. 1985 Sep 5;260(19):10621-8.

引用本文的文献

1
Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes.放射性标记的抗病毒药物和抗体作为病毒特异性成像探针。
Antiviral Res. 2010 Nov;88(2):129-142. doi: 10.1016/j.antiviral.2010.08.005. Epub 2010 Aug 13.
2
Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.E-5-(2-[¹³¹I]碘乙烯基)-2'-脱氧尿苷在犬体内的药代动力学和代谢
Antimicrob Agents Chemother. 1986 Feb;29(2):320-4. doi: 10.1128/AAC.29.2.320.

本文引用的文献

1
Acquisition of thymidine kinase activity by herpes simplex-infected mouse fibroblast cells.单纯疱疹感染的小鼠成纤维细胞获得胸苷激酶活性。
Biochem Biophys Res Commun. 1963 Apr 2;11:55-9. doi: 10.1016/0006-291x(63)90027-5.
2
The decision to biopsy, treat, or wait in suspected herpes encephalitis.
Ann Intern Med. 1980 May;92(5):641-9. doi: 10.7326/0003-4819-92-5-641.
3
Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells.
J Biol Chem. 1981 Jun 25;256(12):5973-6.
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Herpes simplex encephalitis: vidarabine therapy and diagnostic problems.单纯疱疹性脑炎：阿糖腺苷治疗及诊断问题
N Engl J Med. 1981 Feb 5;304(6):313-8. doi: 10.1056/NEJM198102053040602.
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Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus.抗疱疹药物对不同株单纯疱疹病毒的比较疗效
J Infect Dis. 1980 May;141(5):563-74. doi: 10.1093/infdis/141.5.563.
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Evidence for a ninth influenza viral polypeptide.关于第九种流感病毒多肽的证据。
Virology. 1978 Nov;91(1):60-78. doi: 10.1016/0042-6822(78)90355-0.
7
Purification and characterization of proteins excreted by cells infected with herpes simplex virus and their use in diagnosis.单纯疱疹病毒感染细胞所分泌蛋白质的纯化、特性鉴定及其在诊断中的应用。
Virology. 1978 Dec;91(2):234-42. doi: 10.1016/0042-6822(78)90372-0.
8
Simultaneous serum and CSF antibodies in herpes simplex virus encephalitis.单纯疱疹病毒性脑炎中的血清和脑脊液抗体同时检测
JAMA. 1978 Jul 28;240(4):356-60.
9
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.一种抗疱疹剂9-(2-羟乙氧甲基)鸟嘌呤的作用选择性
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716-20. doi: 10.1073/pnas.74.12.5716.
10
Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study.经活检证实的单纯疱疹性脑炎的阿糖腺苷治疗。国立过敏和传染病研究所协作抗病毒研究。
N Engl J Med. 1977 Aug 11;297(6):289-94. doi: 10.1056/NEJM197708112970601.

体外单纯疱疹病毒感染细胞中131I标记的（E）-5-（2-碘乙烯基）-2'-脱氧尿苷的定量摄取研究

Quantitative uptake studies of 131I-labeled (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells in vitro.

作者信息

Gill M J, Samuel J, Wiebe L I, Knaus E E, Tyrrell D L

出版信息

Antimicrob Agents Chemother. 1984 Apr;25(4):476-8. doi: 10.1128/AAC.25.4.476.

DOI:10.1128/AAC.25.4.476
PMID:6732216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185555/
Abstract

We have synthesized a 131I-radiolabeled antiviral compound (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVdU) and shown that this agent was selectively trapped within rabbit kidney cells, infected in vitro by thymidine kinase-positive (TK+) herpes simplex virus (HSV). The uptake of 131I-labeled IVdU was specific, as it was not concentrated within either HSV (TK-) or mock-infected cells. In certain conditions, over 40% of the radiolabel was selectively trapped within HSV (TK+)-infected cells. This was a 20- to 30-fold increase over the uptake of 131I-labeled IVdU by HSV (TK-) or mock-infected cells. The uptake of 131I-labeled IVdU varied directly with (i) the dose of the virus used to infect the rabbit kidney cells; (ii) the concentration of radiolabeled IVdU added to the system; and (iii) the time of exposure of IVdU to infected cells. The ability of this agent to be trapped within HSV (TK+)-infected cells merits further evaluation in animal models as it has potential as a noninvasive, herpes-specific diagnostic test, in particular for HSV encephalitis.

摘要

我们合成了一种131I放射性标记的抗病毒化合物（E）-5-（2-碘乙烯基）-2'-脱氧尿苷（IVdU），并表明该试剂选择性地滞留在体外被胸苷激酶阳性（TK+）单纯疱疹病毒（HSV）感染的兔肾细胞内。131I标记的IVdU摄取具有特异性，因为它在HSV（TK-）或模拟感染的细胞中均未富集。在某些条件下，超过40%的放射性标记选择性地滞留在HSV（TK+）感染的细胞内。这比HSV（TK-）或模拟感染细胞对131I标记的IVdU摄取量增加了20至30倍。131I标记的IVdU摄取量与以下因素直接相关：（i）用于感染兔肾细胞的病毒剂量；（ii）添加到系统中的放射性标记IVdU的浓度；（iii）IVdU与感染细胞的接触时间。该试剂滞留在HSV（TK+）感染细胞内的能力值得在动物模型中进一步评估，因为它有潜力作为一种非侵入性的、针对疱疹的特异性诊断测试，特别是用于HSV脑炎。