Kamaruzzaman Nor Fadhilah, Tan Li Peng, Mat Yazid Khairun Anisa, Saeed Shamsaldeen Ibrahim, Hamdan Ruhil Hayati, Choong Siew Shean, Wong Weng Kin, Chivu Alexandru, Gibson Amanda Jane
Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa 16100, Kelantan, Malaysia.
School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Materials (Basel). 2018 Sep 13;11(9):1705. doi: 10.3390/ma11091705.
Infectious disease caused by pathogenic bacteria continues to be the primary challenge to humanity. Antimicrobial resistance and microbial biofilm formation in part, lead to treatment failures. The formation of biofilms by nosocomial pathogens such as (), (), and () on medical devices and on the surfaces of infected sites bring additional hurdles to existing therapies. In this review, we discuss the challenges encountered by conventional treatment strategies in the clinic. We also provide updates on current on-going research related to the development of novel anti-biofilm technologies. We intend for this review to provide understanding to readers on the current problem in health-care settings and propose new ideas for new intervention strategies to reduce the burden related to microbial infections.
由病原菌引起的传染病仍然是人类面临的主要挑战。抗菌药物耐药性和微生物生物膜的形成在一定程度上导致治疗失败。诸如（）、（）和（）等医院病原体在医疗设备和感染部位表面形成生物膜，给现有治疗带来了额外的障碍。在本综述中，我们讨论了临床常规治疗策略所面临的挑战。我们还提供了与新型抗生物膜技术开发相关的当前正在进行的研究的最新情况。我们希望本综述能让读者了解医疗保健环境中的当前问题，并为新的干预策略提出新思路，以减轻与微生物感染相关的负担。
