Bascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL, 33136, USA.
Bascom Palmer Eye Institute, University of Miami, 900 NW 17th Street, Miami, FL, 33136, USA; Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL, 33125, USA.
Ocul Surf. 2019 Jan;17(1):60-63. doi: 10.1016/j.jtos.2018.09.001. Epub 2018 Sep 11.
To characterize vision-related and psychosocial quality of life (QoL) parameters in medically and surgically treated patients with OSSN.
Forty-one patients with OSSN treated with medical therapy consisting of interferon alpha 2b drops 1 MIU/ml (n = 22) or who underwent surgical excision (n = 19) were contacted. All subjects answered a quality of life assessment with an original questionnaire in which they were asked about a range of parameters. Overall satisfaction and motivating factors for treatment were also reviewed.
The mean age at the time of the survey was 64.6 and 51% were male with similar demographics between groups. Based on the previous cohort, rates of tumor resolution and recurrences were comparable in the two groups. Reasons for choosing a particular treatment varied between the groups. Forty percent of individuals in the medical group reported a fear of surgery (p = 0.03) and often made the decision after personal research (p = 0.008). Thirty-two percent of patients in the surgical group chose surgery due to fear of decreased vision due to lesion growth, therefore wanting immediate resolution (p = 0.09). Drops precipitated more ocular symptoms such as tearing and itchiness, on the other hand, patients who had surgery reported having more pain.
Quality of life considerations before, during, and after OSSN treatment is an important yet understudied topic. Our study is the first to look at QoL parameters in OSSN treatment and we found that patients in both medically and surgically treated groups had similar QoL metric but were driven to choose chemotherapy due to fear of surgery and/or prior literature review.
描述接受药物和手术治疗的 OSSN 患者的视力相关和心理社会生活质量（QoL）参数。
联系了 41 名接受药物治疗（干扰素 α 2b 滴剂 1 MIU/ml，n=22）或手术切除（n=19）的 OSSN 患者。所有患者均使用原始问卷回答了生活质量评估，问卷中询问了一系列参数。还评估了总体满意度和治疗的激励因素。
调查时的平均年龄为 64.6 岁，男性占 51%，两组人群的人口统计学特征相似。基于以前的队列，两组的肿瘤缓解率和复发率相当。选择特定治疗的原因因组而异。药物组中有 40%的人表示害怕手术（p=0.03），并且经常在个人研究后做出决定（p=0.008）。手术组中有 32%的患者因担心病变生长导致视力下降而选择手术，因此希望立即解决（p=0.09）。滴眼剂会引起更多的眼部症状，如流泪和瘙痒，而接受手术的患者则报告疼痛更多。
在 OSSN 治疗之前、期间和之后考虑生活质量是一个重要但研究不足的话题。我们的研究首次观察了 OSSN 治疗中的 QoL 参数，我们发现接受药物和手术治疗的患者的 QoL 指标相似，但由于害怕手术和/或先前的文献综述，他们选择了化疗。
