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棕榈酰抗坏血酸 2-葡萄糖苷有可能保护哺乳动物细胞免受高传能线密度碳离子辐射。

Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation.

机构信息

Department of Environmental & Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO, 80523, USA.

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.

出版信息

Sci Rep. 2018 Sep 14;8(1):13822. doi: 10.1038/s41598-018-31747-1.

DOI:10.1038/s41598-018-31747-1
PMID:30218013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6138748/
Abstract

DMSO, glycerol, and ascorbic acid (AA) are used in pharmaceuticals and known to display radioprotective effects. The present study investigates radioprotective properties of novel glyceryl glucoside, ascorbic acid 2-glucoside, glyceryl ascorbate, and palmitoyl ascorbic acid 2-glucoside (PA). Gamma-rays or high-LET carbon-ions were irradiated in the presence of tested chemicals. Lambda DNA damage, cell survival, and micronuclei formation of CHO cells were analyzed to evaluate radioprotective properties. Radiation-induced Lambda DNA damage was reduced with chemical pre-treatment in a concentration-dependent manner. This confirmed tested chemicals were radical scavengers. For gamma-irradiation, enhanced cell survival and reduction of micronuclei formation were observed for all chemicals. For carbon-ion irradiation, DMSO, glycerol, and PA displayed radioprotection for cell survival. Based on cell survival curves, protection levels by PA were confirmed and comparable between gamma-rays and high-LET carbon-ions. Micronuclei formation was only decreased with AA and a high concentration of glycerol treatment, and not decreased with PA treatment. This suggests that mechanisms of protection against high-LET carbon-ions by PA can differ from normal radical scavenging effects that protect DNA from damage.

摘要

DMSO、甘油和抗坏血酸 (AA) 被用于医药领域，已知具有放射防护作用。本研究探讨了新型甘油葡糖苷、抗坏血酸 2-葡糖苷、甘油抗坏血酸酯和棕榈酰抗坏血酸 2-葡糖苷 (PA) 的放射防护特性。在存在测试化学品的情况下，用 γ 射线或高传能线密度碳离子进行辐照。通过分析 CHO 细胞的 λ DNA 损伤、细胞存活率和微核形成来评估放射防护特性。化学预处理以浓度依赖的方式减少了辐射诱导的 λ DNA 损伤，这证实了测试的化学物质是自由基清除剂。对于 γ 射线辐照，所有化学物质均增强了细胞存活率并减少了微核形成。对于碳离子辐照，DMSO、甘油和 PA 对细胞存活率显示出放射防护作用。基于细胞存活率曲线，确认了 PA 的保护水平，并且在 γ 射线和高传能线密度碳离子之间相当。仅用 AA 和高浓度甘油处理可降低微核形成，而用 PA 处理则不能降低微核形成。这表明，PA 对高传能线密度碳离子的保护机制可能与保护 DNA 免受损伤的正常自由基清除作用不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/d61900b7bf55/41598_2018_31747_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/e8a3986dd289/41598_2018_31747_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/a6a02357e9c3/41598_2018_31747_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/1f3403370de0/41598_2018_31747_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/2c7da2c14ec4/41598_2018_31747_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/d61900b7bf55/41598_2018_31747_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/e8a3986dd289/41598_2018_31747_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/a6a02357e9c3/41598_2018_31747_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/1f3403370de0/41598_2018_31747_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/2c7da2c14ec4/41598_2018_31747_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a6/6138748/d61900b7bf55/41598_2018_31747_Fig5_HTML.jpg

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