Schrier D J, Imre K M
J Immunol. 1986 Nov 15;137(10):3284-9.
Adenosine is a potent physiologic substance with a variety of biologic activities. Many of the effects of adenosine appear to be mediated by two populations of cell-surface adenosine receptors (A1 and A2). We have examined the effects of several adenosine receptor agonists on human neutrophils stimulated with the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP). The results indicate that both superoxide anion generation and degranulation (as assessed by lysozyme release) are inhibited. Inhibition correlated most strongly with A2 receptor affinity for both parameters and was reversible by the adenosine receptor antagonist 8-phenyltheophylline. Because toxic oxygen metabolites and degradative enzymes are implicated in a variety of inflammatory disorders, adenosine agonists may be useful probes to help expand our knowledge of the role of these mediators in human disease.
腺苷是一种具有多种生物活性的强效生理物质。腺苷的许多作用似乎是由两类细胞表面腺苷受体（A1和A2）介导的。我们研究了几种腺苷受体激动剂对用趋化肽N-甲酰甲硫氨酰亮氨酰苯丙氨酸（FMLP）刺激的人中性粒细胞的影响。结果表明，超氧阴离子的产生和脱颗粒（通过溶菌酶释放评估）均受到抑制。对于这两个参数，抑制作用与A2受体亲和力的相关性最强，并且可被腺苷受体拮抗剂8-苯基茶碱逆转。由于毒性氧代谢产物和降解酶与多种炎症性疾病有关，腺苷激动剂可能是有用的探针，有助于扩展我们对这些介质在人类疾病中作用的认识。
