College of Life Information Science & Instrument Engineering, Hangzhou Dianzi University, Hangzhou, PR China; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR.
Department of Statistics, Faculty of Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan, PR China.
Gene. 2018 Dec 30;679:360-368. doi: 10.1016/j.gene.2018.09.023. Epub 2018 Sep 12.
Vertebrate genomes have been considered to have undergone a complicated evolution during their early period and to have generated a large number of genetic templates with novel functions, such as an extended spinal cord and a dorsal central nervous system. However, consistent gene evolution in vertebrate genomes has not been fully elucidated. In this study, we have systematically investigated the gene evolution in vertebrates utilizing a series of comparative genomics tools. We determined that three critical genes were consistently lost in vertebrate genomes, and 14 genes initially emerged in vertebrate formation. Furthermore, another 29 genes were identified with consistent amino acid variation between the vertebrates and invertebrates. A function analysis of five genes (TEP3, ABLIM2, ABLIM3, GAD1 and GAD2) was performed, and their evolution mechanisms in vertebrate genomes further investigated. These findings provide novel insights for studying the vertebrate evolution and spine development.
脊椎动物的基因组在早期经历了复杂的进化，产生了大量具有新功能的遗传模板，如延长的脊髓和背侧中枢神经系统。然而，脊椎动物基因组中的一致基因进化尚未得到充分阐明。在这项研究中，我们利用一系列比较基因组学工具系统地研究了脊椎动物的基因进化。我们确定了三个关键基因在脊椎动物基因组中持续丢失，14 个基因最初在脊椎动物形成时出现。此外，还有另外 29 个基因在脊椎动物和无脊椎动物之间具有一致的氨基酸变异。对五个基因（TEP3、ABLIM2、ABLIM3、GAD1 和 GAD2）的功能进行了分析，并进一步研究了它们在脊椎动物基因组中的进化机制。这些发现为研究脊椎动物进化和脊柱发育提供了新的见解。
