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间充质干细胞对一种在体外对人类恶性癌细胞系有活性的阳离子铂（II）配合物的摄取-释放。

Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines.

作者信息

Rimoldi Isabella, Coccè Valentina, Facchetti Giorgio, Alessandri Giulio, Brini Anna Teresa, Sisto Francesca, Parati Eugenio, Cavicchini Loredana, Lucchini Giorgio, Petrella Francesco, Ciusani Emilio, Pessina Augusto

机构信息

Department of Pharmaceutical Science, University of Milan, Via Venezian 21, 20133 Milan, Italy.

CRC StaMeTec-Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy.

出版信息

Biomed Pharmacother. 2018 Dec;108:111-118. doi: 10.1016/j.biopha.2018.09.040. Epub 2018 Sep 12.

DOI:10.1016/j.biopha.2018.09.040
PMID:30218855
Abstract

In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(II)-complex) and their in vitro activity (antiproliferative and anti-angiogenic properties) were investigated against three aggressive human tumor cell lines. caPt(II)-complex shown a high stability until 9 days of treatment and displayed a significant and higher activity than CisPt against both NCI-H28 mesothelioma (19.37 ± 9.57 μM versus 34.66 ± 7.65 μM for CisPt) and U87 MG glioblastoma (19.85 ± 0.97 μM versus 54.14 ± 3.19 for CisPt). Mesenchymal Stromal Cells (AT-MSCs) showed a significant different sensitivity (IC = 71.9 ± 15.1 μM for caPt(II)-complex and 8.7 ± 4.5 μM for CisPt) to the antiproliferative activity of caPt(II)-complex and CisPt. The ability of MSCs to uptake both the drugs in a similar amount of 2.49 pM /cell, suggested a possible development of new therapies based on cell mediated drug delivery.

摘要

在本研究中，研究了顺铂（CisPt）和阳离子铂（II）配合物（caPt（II）-配合物）的体外稳定性及其对三种侵袭性人类肿瘤细胞系的体外活性（抗增殖和抗血管生成特性）。caPt（II）-配合物在治疗9天前显示出高稳定性，并且在抗NCI-H28间皮瘤（CisPt为34.66±7.65μM，caPt（II）-配合物为19.37±9.57μM）和U87 MG胶质母细胞瘤（CisPt为54.14±3.19，caPt（II）-配合物为19.85±0.97μM）方面均表现出比CisPt显著更高的活性。间充质基质细胞（AT-MSCs）对caPt（II）-配合物和CisPt的抗增殖活性表现出显著不同的敏感性（caPt（II）-配合物的IC = 71.9±15.1μM，CisPt为8.7±4.5μM）。MSCs以相似的量（2.49 pM/细胞）摄取两种药物的能力，提示基于细胞介导的药物递送的新疗法可能的发展。

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[3]
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[4]
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[5]
In Vitro Activity of Monofunctional Pt-II Complex Based on 8-Aminoquinoline against Human Glioblastoma.

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[6]
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[7]
Reactions with Proteins of Three Novel Anticancer Platinum(II) Complexes Bearing N-Heterocyclic Ligands.

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[8]
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[9]
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[10]
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