Babajani Amirhesam, Soltani Pegah, Jamshidi Elham, Farjoo Mohammad Hadi, Niknejad Hassan
Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Bioeng Biotechnol. 2020 Jul 23;8:748. doi: 10.3389/fbioe.2020.00748. eCollection 2020.
Mesenchymal stem cells (MSCs), as an undifferentiated group of adult multipotent cells, have remarkable antitumor features that bring them up as a novel choice to treat cancers. MSCs are capable of altering the behavior of cells in the tumor microenvironment, inducing an anti-inflammatory effect in tumor cells, inhibiting tumor angiogenesis, and preventing metastasis. Besides, MSCs can induce apoptosis and inhibit the proliferation of tumor cells. The ability of MSCs to be loaded with chemotherapeutic drugs and release them in the site of primary and metastatic neoplasms makes them a preferable choice as targeted drug delivery procedure. Targeted drug delivery minimizes unexpected side effects of chemotherapeutic drugs and improves clinical outcomes. This review focuses on recent advances on innate antineoplastic features of MSCs and the effect of chemotherapeutic drugs on viability, proliferation, and the regenerative capacity of various kinds of MSCs. It also discusses the efficacy and mechanisms of drug loading and releasing procedures along with and preclinical outcomes of antineoplastic effects of primed MSCs for clinical prospection.
间充质干细胞（MSCs）作为一群未分化的成体多能细胞，具有显著的抗肿瘤特性，使其成为治疗癌症的新选择。间充质干细胞能够改变肿瘤微环境中细胞的行为，在肿瘤细胞中诱导抗炎作用，抑制肿瘤血管生成，并防止转移。此外，间充质干细胞可以诱导肿瘤细胞凋亡并抑制其增殖。间充质干细胞负载化疗药物并在原发性和转移性肿瘤部位释放的能力，使其成为靶向药物递送方法的优选选择。靶向药物递送可将化疗药物的意外副作用降至最低，并改善临床结果。本综述重点关注间充质干细胞固有抗肿瘤特性的最新进展，以及化疗药物对各种间充质干细胞的活力、增殖和再生能力的影响。它还讨论了药物负载和释放程序的功效和机制，以及预处理间充质干细胞抗肿瘤作用的临床前结果，以供临床展望。
