Wutke K, Müller E, Dittrich P
Z Gesamte Inn Med. 1978 Sep 15;33(18):670-3.
It is reported on course and problems of the diagnosis of a lupus erythematodes visceralis with epilepsy. In the demonstrated case the initial stage was characterized by the nearly simultaneous appearance of relapsing arthritides and epilepsy. The diagnosis was made in the stage of an acute exacerbation with cardiac symptomatology which began after the medicamentous treatment with diphenylhydantoin. Up to this moment an oligosymptomatic lupus erythematodes visceralis had not yet been diagnosed. Anamnestic data and the laboratory-clinical findings of the further course of the disease proved the actual lupus erythematodes visceralis. It is referred to the necessity of an aimed anamnesis and a determination of the antinuclear factors before every application ofhydantoin derivations when an epilepsy and joint symptomatology are present.
报道了内脏型红斑狼疮伴癫痫的病程及诊断问题。在所示病例中,初期表现为复发性关节炎和癫痫几乎同时出现。诊断是在使用苯妥英进行药物治疗后出现心脏症状的急性加重期做出的。在此之前,尚未诊断出症状轻微的内脏型红斑狼疮。既往史资料以及疾病进一步发展过程中的实验室临床检查结果证实了实际存在的内脏型红斑狼疮。文中指出,当出现癫痫和关节症状时,在每次使用苯妥英衍生物之前,有必要进行针对性的既往史询问并测定抗核因子。