Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium; Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium; Department of Otorhinolaryngology and Head and Neck Surgery, RHMS Baudour, EpiCURA Hospital, Baudour, Belgium; Department of Otorhinolaryngology and Head and Neck Surgery, Faculté de medicine, CHU Saint-Pierre, Université Libre de Bruxelles, Bruxelles, Belgium.
Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium; Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Liege, Liege, Belgium.
J Voice. 2020 Jan;34(1):112-120. doi: 10.1016/j.jvoice.2018.08.018. Epub 2018 Sep 13.
To study the usefulness of voice quality as therapeutic outcome in laryngopharyngeal reflux disease.
A total of 80 patients with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were treated with pantoprazole, diet, and lifestyle recommendations for 3 months. The therapeutic effectiveness was assessed with RSI; RFS; Voice Handicap Index; blinded Grade, Roughness, Breathiness, Asthenia, Strain, and Instability (GRBASI); aerodynamic and a panel of acoustic measurements before and after treatment. A correlation analysis between symptoms, videolaryngostroboscopic signs, and acoustic measurements was conducted.
Compared to baseline, means of RSI, RFS, Voice Handicap Index, perceptual dysphonia, and roughness significantly decreased. Significant improvements of phonatory quotient, percent jitter, percent shimmer, Relative Average Perturbation, Pitch Perturbation Quotient, Phonatory F0 Range, Amplitude Perturbation Quotient, smooth Amplitude Perturbation Quotient, and Peak-to-Peak Amplitude Variation were found at the end of treatment. Studies of correlation did not identify relevant correlation between videolaryngostroboscopic signs, especially vocal folds edema, and objective voice quality evaluations.
Voice quality assessments can help to better understand voice disorders and can be used as indicators of the treatment effectiveness in patients with laryngopharyngeal reflux-related symptoms.
研究嗓音质量作为咽喉反流病（LPRD）治疗结果的有用性。
共 80 例反流发现评分（RFS）>7 和反流症状指数（RSI）>13 的患者接受泮托拉唑、饮食和生活方式建议治疗 3 个月。治疗效果采用 RSI、RFS、嗓音障碍指数、盲法分级、粗糙度、呼吸声、无力、紧张和不稳定性（GRBASI）、空气动力学和一系列声学测量进行评估。治疗前后进行症状、频闪喉镜征象和声学测量之间的相关性分析。
与基线相比，RSI、RFS、嗓音障碍指数、感知性发声障碍和粗糙度的平均值显著降低。在治疗结束时，发现发音商数、抖动百分比、颤抖百分比、相对平均扰动、音高扰动率、发声 F0 范围、幅度扰动率、平滑幅度扰动率、峰峰幅度变化率显著改善。研究相关性未发现频闪喉镜征象，尤其是声带水肿与客观嗓音质量评估之间存在相关性。
嗓音质量评估有助于更好地了解嗓音障碍，并可作为治疗 LPRD 相关症状患者的治疗效果的指标。
