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大鼠脑信使核糖核酸异质家族的结构特征

Structural characterization of a heterogeneous family of rat brain mRNAs.

作者信息

Tsou A P, Lai C, Danielson P, Noonan D J, Sutcliffe J G

出版信息

Mol Cell Biol. 1986 Mar;6(3):768-78. doi: 10.1128/mcb.6.3.768-778.1986.

DOI:10.1128/mcb.6.3.768-778.1986
PMID:3022128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367577/
Abstract

A large heterogeneous family of RNAs derived from a single rat gene contains members that differ from each other at one or more of three positions. Their 5' ends are nested and transcription can begin at 22 or more sites covering 265 nucleotides. Many of the 5' ends are detectable only in brain RNAs, and even 5' ends common with other tissues appear with different absolute and relative abundances in brain RNA. The central portions of the RNAs are of two forms, differing only by the presence or absence of 17 nucleotides; these forms are probably produced by alternative splicing. Polyadenylation occurs at either of two sites. This complicated family of 88 RNAs encodes two novel putative proteins that differ at their C termini.

摘要

一个源自单个大鼠基因的庞大异质性RNA家族，其成员在三个位置中的一个或多个位置上彼此不同。它们的5'端是嵌套的，转录可以从22个或更多位点开始，覆盖265个核苷酸。许多5'端仅在脑RNA中可检测到，甚至与其他组织共有的5'端在脑RNA中也以不同的绝对和相对丰度出现。RNA的中央部分有两种形式，仅因17个核苷酸的有无而不同；这些形式可能是由可变剪接产生的。聚腺苷酸化发生在两个位点中的任意一个。这个由88个RNA组成的复杂家族编码两种新的推定蛋白，它们的C末端不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/aa4f7f5155e9/molcellb00087-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/bb5d6f4c29e8/molcellb00087-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/1e10ed6d5b76/molcellb00087-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/8b261a6fc28a/molcellb00087-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/0211642488d4/molcellb00087-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/ce4dc6bd7400/molcellb00087-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/aa4f7f5155e9/molcellb00087-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/bb5d6f4c29e8/molcellb00087-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/1e10ed6d5b76/molcellb00087-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/8b261a6fc28a/molcellb00087-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/0211642488d4/molcellb00087-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/ce4dc6bd7400/molcellb00087-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ff8/367577/aa4f7f5155e9/molcellb00087-0040-a.jpg

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本文引用的文献

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