Collet Carlos, Mizukami Takuya, Grundeken Maik J
a Amsterdam Heart Center, Department of Cardiology , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.
b Universitair Ziekenhuis Brussels , University of Brussels , Brussel , Belgium.
Expert Rev Cardiovasc Ther. 2018 Oct;16(10):725-734. doi: 10.1080/14779072.2018.1523717. Epub 2018 Oct 3.
Treatment of coronary bifurcation lesions with contemporary state-of-the-art percutaneous coronary intervention (PCI) is still associated with higher rate of adverse cardiovascular events compared to non-bifurcation lesions. Bench testing and virtual computer modeling have increased our understanding of bifurcation PCI guiding refinement in bifurcation techniques. New insights on bifurcation PCI have the potential to further improve clinical outcomes in patients presenting with bifurcation lesions. Areas covered: The present manuscript aims to review the methods for bifurcation lesion assessment and treatment strategy step by step supported on bench and clinical evidence. Expert commentary: Invasive pressure-wire evaluation is essential to determine the appropriateness of bifurcation PCI, particularly in intermediate coronary stenosis. Treatment strategy relies on four parameters: diameters of the three segments of the bifurcation; lesion length and plaque distribution; and bifurcation angle. The optimal technique for bifurcation PCI is still debated, an individualized approach with an initial provisional side branch stenting strategy seems to be suitable in the 75 to 95% of patients. For more complex bifurcations, two-stent techniques may be required with increasing evidence supporting the usefulness of the double kissing balloon crush (DK-crush) technique.
与非分叉病变相比,采用当代先进的经皮冠状动脉介入治疗(PCI)技术治疗冠状动脉分叉病变,其不良心血管事件发生率仍然较高。体外试验和虚拟计算机建模增进了我们对分叉病变PCI的理解,有助于改进分叉技术。关于分叉病变PCI的新见解有可能进一步改善分叉病变患者的临床结局。涵盖领域:本文旨在依据体外试验和临床证据,逐步回顾分叉病变评估方法及治疗策略。专家评论:有创压力导丝评估对于确定分叉病变PCI的适宜性至关重要,尤其是在冠状动脉中度狭窄时。治疗策略取决于四个参数:分叉三个节段的直径;病变长度和斑块分布;以及分叉角度。分叉病变PCI的最佳技术仍存在争议,对于75%至95%的患者,采用初始临时边支支架置入策略的个体化方法似乎是合适的。对于更复杂的分叉病变,可能需要采用双支架技术,越来越多的证据支持双吻球囊挤压(DK-挤压)技术的有效性。