Willer J C, Roby A, Ernst M
Neuropharmacology. 1986 Aug;25(8):819-22. doi: 10.1016/0028-3908(86)90004-3.
The effects of intravenous administration of 2.5 mg/kg of GB 52, a highly potent derivative of the enkephalinase inhibitor, thiorphan, were studied on the threshold of both the nociceptive reflex (Tr) and sensation of pain (Tp) as well as on the thresholds of both recruitment of the maximal nociceptive reflex response (Tmr) and tolerable pain (Tip), elicited by electrical stimulation of the sural nerve in normal and relaxed volunteers. It was found that neither the nociceptive motor responses (Tr and Tmr) nor the subjective reports of pain (Tp and Tip), were significantly affected by GB 52. It is concluded that, in the experimental conditions used, the transmission of nociceptive messages at the spinal level is not tonically modulated by any enkephalinergic system.
研究了静脉注射2.5毫克/千克GB 52（脑啡肽酶抑制剂硫喷妥的一种高效衍生物）对正常放松志愿者腓肠神经电刺激诱发的伤害性反射阈值（Tr）和疼痛感觉阈值（Tp）以及最大伤害性反射反应募集阈值（Tmr）和可耐受疼痛阈值（Tip）的影响。结果发现，GB 52对伤害性运动反应（Tr和Tmr）以及疼痛的主观报告（Tp和Tip）均无显著影响。得出的结论是，在所用的实验条件下，脊髓水平的伤害性信息传递不受任何脑啡肽能系统的紧张性调节。
