Headley P M, O'Shaughnessy C T
Neuropharmacology. 1986 Aug;25(8):919-22. doi: 10.1016/0028-3908(86)90020-1.
The effect of morphine and naloxone on basal and forskolin-stimulated efflux of cyclic AMP from rat striatal slices was examined. Neither morphine nor naloxone had any consistent effect on the basal efflux of cyclic AMP. Forskolin produced a time and dose-dependent enhancement of cyclic AMP efflux. Neither morphine nor naloxone affected this forskolin-enhanced release. These results suggest that measurements of cyclic AMP released from brain slices do not accurately reflect effects on adenylate cyclase inhibition by opiates.
研究了吗啡和纳洛酮对大鼠纹状体切片中环磷酸腺苷（cAMP）基础释放及福斯高林刺激释放的影响。吗啡和纳洛酮对cAMP的基础释放均无一致的影响。福斯高林使cAMP释放呈时间和剂量依赖性增强。吗啡和纳洛酮均不影响福斯高林增强的这种释放。这些结果表明，对脑切片释放的cAMP进行测量并不能准确反映阿片类药物对腺苷酸环化酶抑制的作用。
