Liehn J C, Hannequin P, Fortier A, Elaerts J, Valeyre J
Nucl Med Commun. 1986 Sep;7(9):697-704.
One hundred and twenty eight patients with suspected or proven CAD were investigated using both X-ray ventriculography and equilibrium gated radionuclide angiography. In order to diagnose regional wall motion abnormalities, the parametric images obtained by Fourier analysis of the radionuclide images were analysed by different automated methods based on the measurement of the homogeneity of the phase values within the LV ROI. The effect of a diastolic frames exclusion, smoothing the original data, weighting the phase histogram, using Bacharach's error corrected phase distribution functions, using different descriptors of the spread of the phase histograms or distribution functions were tested. Using the results of the X-ray examination as the gold standard, ROC curves were plotted for each method. The ROC curves were modelled by a binormal model using the maximum likelihood method. Statistical tests were applied on the area under the ROC curves. The results show that the diagnostic value of the automated methods depends mainly on the way the histograms or distribution functions are described and to a lesser extent on the type of histograms or distribution functions used. The best result is obtained after smoothing, diastolic frames exclusion, weighting the phase histogram by the amplitude and describing it by its standard deviation. Nevertheless, this result is not significantly different from the result obtained by visual analysis of the phase and amplitude images.
对128例疑似或确诊为冠心病的患者同时采用X线心室造影和平衡门控放射性核素血管造影进行检查。为了诊断局部室壁运动异常，基于左心室感兴趣区内相位值均匀性的测量，采用不同的自动方法对通过放射性核素图像的傅里叶分析获得的参数图像进行分析。测试了排除舒张期帧、对原始数据进行平滑处理、对相位直方图加权、使用巴卡拉赫误差校正相位分布函数、使用相位直方图或分布函数离散度的不同描述符的效果。以X线检查结果作为金标准，为每种方法绘制受试者工作特征（ROC）曲线。使用最大似然法通过双正态模型对ROC曲线进行建模。对ROC曲线下面积进行统计检验。结果表明，自动方法的诊断价值主要取决于直方图或分布函数的描述方式，在较小程度上取决于所使用的直方图或分布函数的类型。在进行平滑处理、排除舒张期帧、按幅度对相位直方图加权并通过其标准差进行描述后，可获得最佳结果。然而，该结果与通过对相位和幅度图像进行视觉分析所获得的结果并无显著差异。
