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他非诺喹

Tafenoquine

Abstract

No information is available on the use of tafenoquine during breastfeeding. The amounts in milk are acceptable if the infant is not glucose-6-phosphate dehydrogenase (G6PD) deficient, but tafenoquine can cause hemolysis in patients with G6PD deficiency. If tafenoquine is needed by the mother, testing the mother and infant for G6PD deficiency is required before the drug is given. Because the half-life of tafenoquine averages 15 days, the manufacturer recommends that breastfeeding should not breastfeed for 3 months after the dose if the infant is G6PD deficient, which implies complete cessation of nursing.

摘要

关于在母乳喂养期间使用他非诺喹的信息尚无可用资料。他非诺喹可导致葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症患者发生溶血。如果母亲需要使用他非诺喹,在给药前需对母亲和婴儿进行G6PD缺乏症检测。由于他非诺喹的半衰期平均为15天,制造商建议,如果婴儿G6PD缺乏,母亲在给药后3个月内不应进行母乳喂养。

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