Division of Paleopathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa,
Division of Paleopathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Pathobiology. 2018;85(5-6):289-299. doi: 10.1159/000490798. Epub 2018 Sep 17.
This study describes and discusses a rare case of metastatic carcinoma that affected the skeleton of an adult male recovered in the necropolis of Casal Bertone in Rome (Italy). The necropolis, which dates back to the Imperial Age (1st to 2nd century AD), is located near some residential structures and a large place identified as a fullery (fullonica).
Anthropological and paleopathological studies of the skeletal remains were performed via careful macroscopic, microscopic, radiological (X-ray and CT scan), and histological investigation.
The skeleton displayed mixed osteoclastic and osteoblastic lesions that mainly involved the axial bones, in particular the sternum, the ribs, the spine, and the scapular and pelvic girdles. The anatomical distribution and the destructive and proliferative nature of the lesions suggested diffuse metastases arising from a soft-tissue primary cancer. The age and sex of the individual, as well as radiographic and histological pictures, allowed diagnosis of an advanced prostate cancer with extensively diffused bone metastases.
At present, this is the only case of prostate cancer from the Imperial Age recovered in Rome.
本研究描述并讨论了一例罕见的转移性癌病例，该病例影响了在罗马（意大利）卡萨尔·伯特龙（Casal Bertone）墓地中发现的一名成年男性的骨骼。该墓地可追溯至罗马帝国时期（公元 1 至 2 世纪），位于一些住宅建筑和一个被确定为洗染坊（fullonica）的大型场所附近。
通过仔细的宏观、微观、放射学（X 射线和 CT 扫描）和组织学研究对骨骼遗骸进行了人类学和古病理学研究。
骨骼显示出混合性破骨细胞和成骨细胞病变，主要涉及轴骨，特别是胸骨、肋骨、脊柱以及肩胛带和骨盆带。病变的解剖分布以及破坏和增生的性质提示源于软组织原发性癌症的弥漫性转移。个体的年龄和性别，以及影像学和组织学图片，诊断为广泛扩散的前列腺癌伴骨转移。
目前，这是在罗马发现的唯一一例来自罗马帝国时期的前列腺癌病例。
