Khuong Mai Duy, Lee Joomin, Min Ilgi, Vales Temmy Pegarro, Choi Kyong-Hoon, Park Bong Joo, Cho Sung, Kim Ho-Joong
Department of Chemistry, Chosun University, Gwangju 61452, Korea.
Department of Chemistry, Chonnam National University, Gwangju 61186, Korea.
Nanomaterials (Basel). 2018 Sep 15;8(9):728. doi: 10.3390/nano8090728.
In this study, a series of rationally designed emissive phenanthrene derivatives were synthesized and their aggregation-induced emission (AIE) properties in tetrahydrofuran (THF)/water mixtures were investigated. Two tetraphenylethene (TPE) segments were conjugated to both ends of the phenanthrene core at the -positions and -positions, resulting in pTPEP and mTPEP derivatives, respectively. While the TPE-conjugated phenanthrene derivatives did not show any emission when dissolved in pure THF, they showed strong sky-blue emissions in water-THF mixtures, which is attributed to the restriction of intramolecular motions of TPE segments by aggregation. Furthermore, silica nanoparticles loaded with these AIE-active compounds were prepared and proved to be promising intracellular imaging agents.
在本研究中，合成了一系列经过合理设计的发光菲衍生物，并研究了它们在四氢呋喃（THF）/水混合物中的聚集诱导发光（AIE）性质。两个四苯乙烯（TPE）片段分别在菲核的α位和β位与菲核两端共轭，分别得到pTPEP和mTPEP衍生物。虽然TPE共轭菲衍生物溶解在纯THF中时不显示任何发射，但它们在水-THF混合物中显示出强烈的天蓝色发射，这归因于聚集对TPE片段分子内运动的限制。此外，制备了负载这些AIE活性化合物的二氧化硅纳米颗粒，并证明它们是有前途的细胞内成像剂。
