Department of Chemistry, Bioengineering Graduate Program, Nano Science and Technology Program, Institute of Molecular Functional Materials, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China.
Chemistry. 2010 Apr 12;16(14):4266-72. doi: 10.1002/chem.200901823.
Highly emissive inorganic-organic nanoparticles with core-shell structures are fabricated by a one-pot, surfactant-free hybridization process. The surfactant-free sol-gel reactions of tetraphenylethene- (TPE) and silole-functionalized siloxanes followed by reactions with tetraethoxysilane afford fluorescent silica nanoparticles FSNP-1 and FSNP-2, respectively. The FSNPs are uniformly sized, surface-charged and colloidally stable. The diameters of the FSNPs are tunable in the range of 45-295 nm by changing the reaction conditions. Whereas their TPE and silole precursors are non-emissive, the FSNPs strongly emit in the visible vision, as a result of the novel aggregation-induced emission (AIE) characteristics of the TPE and silole aggregates in the hybrid nanoparticles. The FSNPs pose no toxicity to living cells and can be utilized to selectively image cytoplasm of HeLa cells.
通过一锅无表面活性剂的杂交工艺，制备了具有核壳结构的高发光无机-有机纳米粒子。四苯乙烯-（TPE）和硅烷功能化硅氧烷的无表面活性剂溶胶-凝胶反应，然后与四乙氧基硅烷反应，分别得到荧光二氧化硅纳米粒子 FSNP-1 和 FSNP-2。FSNPs 尺寸均匀，带表面电荷，胶体稳定。通过改变反应条件，FSNPs 的直径在 45-295nm 范围内可调。虽然 TPE 和硅氧烷前体没有发光，但 FSNPs 由于 TPE 和硅氧烷在杂化纳米粒子中的新型聚集诱导发光（AIE）特性而在可见光区强烈发光。FSNPs 对活细胞没有毒性，可用于选择性地对 HeLa 细胞的细胞质成像。
