IKK相关激酶TBK1和IKKε在癌症中的作用。
Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer.
作者信息
Durand Joel K, Zhang Qing, Baldwin Albert S
机构信息
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Cells. 2018 Sep 15;7(9):139. doi: 10.3390/cells7090139.
While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases control proliferation, autophagy, cell survival, and cancer immune responses. Here we review the involvement of TBK1 and IKKε in controlling different cancers and in regulating responses to cancer immunotherapy.
虽然主要研究它们在先天免疫反应中的作用，但IκB激酶（IKK）相关激酶——衔接蛋白激酶1（TBK1）和IKKε也在多种癌症中促进致癌表型。此外，这些激酶的几种底物控制细胞增殖、自噬、细胞存活和癌症免疫反应。在此，我们综述TBK1和IKKε在控制不同癌症以及调节癌症免疫治疗反应中的作用。
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