Woolcock Institute of Medical Research, The University of Sydney, Glebe New South Wales, Sydney, NSW, 2037, Australia.
Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia.
Respir Res. 2018 Sep 17;19(1):176. doi: 10.1186/s12931-018-0880-2.
There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.
在气道炎症与固定气流阻塞（FAO）的老年非吸烟哮喘患者的肺功能损害之间存在有限的证据，即使使用吸入皮质类固醇（ICS）治疗也可能发生这种情况。我们在接受高剂量 ICS/长效β激动剂治疗 2 个月后，通过支气管肺泡灌洗（BAL）评估了非吸烟成人哮喘患者的肺功能（肺活量测定法，强迫振荡技术（FOT））、肺弹性回缩和气道炎症。研究对象表现为中度 FAO、异常 FOT 指数和肺弹性回缩丧失。这项横断面研究表明，BAL 中的中性粒细胞、嗜酸性粒细胞、炎症细胞因子与肺功能损害之间没有关系。其他炎症途径或炎症随时间对肺功能的影响可能解释了 FAO 的发展。
