六氯苯中毒时大鼠肝细胞膜损伤及其乙醇增强作用
Rat liver plasma membrane damage in hexachlorobenzene intoxication and its potentiation by ethanol.
作者信息
Nikolaev V, Naydenova E, Kerimova M, Dimov S, Ivanov E
出版信息
Toxicol Lett. 1986 Sep;32(3):269-73. doi: 10.1016/0378-4274(86)90118-9.
Chronic feeding of male Wistar rats with food containing hexachlorobenzene (HCB) at 17.5 mmol/kg induced elevation of serum amino-transferases and bilirubin content, increase of microsomal cytochrome P-450 concentration, and decrease of 5'-nucleotidase, K+,Na+- and Mg2+-adenosine triphosphatase activities in liver plasma membrane preparations. These changes were potentiated by ethanol consumption suggesting a possible role of liver plasma membrane damage in the pathogenesis of HCB intoxication.
用含17.5 mmol/kg六氯苯（HCB）的食物长期喂养雄性Wistar大鼠，可导致血清氨基转移酶升高、胆红素含量增加、微粒体细胞色素P-450浓度升高，以及肝细胞膜制剂中5'-核苷酸酶、K⁺、Na⁺-和Mg²⁺-三磷酸腺苷酶活性降低。乙醇摄入会加剧这些变化，提示肝细胞膜损伤在HCB中毒发病机制中可能起作用。
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