Nikolaev V, Naydenova E, Kerimova M, Dimov S, Ivanov E, Tchernev K
Arch Toxicol. 1987;60(1-3):112-4. doi: 10.1007/BF00296961.
Male Wistar rats fed for 60 days a glucose diet containing 17.5 mmol hexachlorobenzene/kg show a less pronounced increase in serum parameters and microsomal cytochrome P-450 concentration and a lower decrease in liver plasma membrane 5'-nucleotidase, K+, Na+- and Mg++-adenosine triphosphatase activities than the controls fed standard diet + hexachlorobenzene. Addition of 10% ethanol to the drinking water eliminates the "glucose effect". The glucose diet and ethanol exert contrasting effects on microsomal enzyme induction and liver plasma membrane damage in hexachlorobenzene intoxication.
用含17.5 mmol六氯苯/千克葡萄糖饮食喂养60天的雄性Wistar大鼠，与用标准饮食加六氯苯喂养的对照组相比，其血清参数和微粒体细胞色素P - 450浓度的升高不太明显，肝细胞膜5'-核苷酸酶、钾离子、钠离子和镁离子三磷酸腺苷酶活性的降低也较少。在饮用水中添加10%的乙醇可消除“葡萄糖效应”。在六氯苯中毒中，葡萄糖饮食和乙醇对微粒体酶诱导和肝细胞膜损伤产生相反的影响。
