Jones B R, Johnstone A C, Cahill J I, Hancock W S
Vet Rec. 1986 Sep 13;119(11):268-72. doi: 10.1136/vr.119.11.268.
Primary hyperlipoproteinaemia (hyperchylomicronaemia) with a slight increase in very low density lipoprotein) is described in 20 cats. Fasting hyperlipaemia, lipaemia retinalis and peripheral neuropathies were the most frequently detected clinical signs. The disease is thought to be inherited as an autosomal recessive trait but the exact mode of inheritance has not been determined. Affected cats showed reduced lipoprotein lipase activity measured after heparin activation compared with the response in normal cats. Plasma triglyceride and cholesterol were increased in all the cats with the major proportion of triglyceride and cholesterol being present in chylomicrons. The peripheral nerve lesions were caused by compression of nerves by lipid granulomata. It is probable that the lipid granulomata result from trauma because the nerves most often affected were at sites like the spinal foraminae where they were susceptible to trauma.
在20只猫中发现了原发性高脂蛋白血症（高乳糜微粒血症），伴有极低密度脂蛋白略有升高。空腹高脂血症、视网膜脂血症和周围神经病变是最常检测到的临床症状。该病被认为是作为常染色体隐性性状遗传，但确切的遗传模式尚未确定。与正常猫相比，受影响的猫在肝素激活后测得的脂蛋白脂肪酶活性降低。所有猫的血浆甘油三酯和胆固醇均升高，其中大部分甘油三酯和胆固醇存在于乳糜微粒中。周围神经病变是由脂质肉芽肿压迫神经所致。脂质肉芽肿很可能是由创伤引起的，因为最常受影响的神经位于脊髓孔等易受创伤的部位。
