Thompson J C, Johnstone A C, Jones B R, Hancock W S
Department of Veterinary Clinical Sciences, Massey University, Palmerston North, New Zealand.
J Comp Pathol. 1989 Oct;101(3):251-62. doi: 10.1016/0021-9975(89)90034-0.
The ultrastructural pathology of cats suffering from familial lipoprotein lipase deficiency is described. There were large numbers of lipid vacuoles within hepatocytes, epithelial cells of the proximal convoluted tubule of kidney and macrophages of the liver, spleen and lymph node. The older cats tended to have larger quantities of ceroid within hepatocytes and macrophages, and all stages of development of ceroid were observed. Chylomicron emboli were seen within the glomerular capillaries and interlobular blood vessels. There was podocyte foot fusion and thickening of basement membranes of glomeruli, Bowman's capsule and some proximal convoluted tubules, similar to that seen in diabetes mellitus. These changes represent a non-specific reaction of the kidney to noxious insults such as hypoxia caused by emboli. Transformation of smooth muscle cells from a contractile to a synthetic state was seen in the splenic trabeculae and, to a lesser extent, in blood vessels. Dilatations of the nuclear membrane of the lymphocytes were noted, the significance of which is unknown.
描述了患有家族性脂蛋白脂肪酶缺乏症的猫的超微结构病理学。肝细胞、肾近端曲管上皮细胞以及肝、脾和淋巴结的巨噬细胞内有大量脂质空泡。年龄较大的猫肝细胞和巨噬细胞内往往有更多的脂褐素，且观察到了脂褐素的各个发育阶段。在肾小球毛细血管和小叶间血管内可见乳糜微粒栓子。肾小球、鲍曼囊和一些近端曲管的足细胞足融合，基底膜增厚，类似于糖尿病所见。这些变化代表肾脏对诸如栓子引起的缺氧等有害损伤的非特异性反应。在脾小梁中可见平滑肌细胞从收缩状态转变为合成状态，在血管中程度较轻。注意到淋巴细胞的核膜扩张，其意义尚不清楚。
