Schmitz Marylin, Roux Xavier, Huttner Benedikt, Pugin Jérôme
Division of Intensive Care, Faculty of Medicine Geneva, University Hospitals of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland.
Division of Infectious Diseases, Faculty of Medicine Geneva, University Hospitals of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland.
Ann Intensive Care. 2018 Sep 17;8(1):88. doi: 10.1186/s13613-018-0438-y.
The streptococcal toxic shock syndrome is a severe complication associated with invasive infections by group A streptococci. In spite of medical progresses in the care of patients with septic shock during the last decades, this condition has remained associated with a high mortality. Early recognition and multidisciplinary management are key to the care of patients with streptococcal toxic shock syndrome, with intensive and appropriate intensive support of failing organs, rapid diagnosis of infectious source(s), and surgical management. The epidemiology and risk factors for streptococcal toxic shock syndrome remain to be better studied, including the possible causal role of exposure to nonsteroidal anti-inflammatory drugs. In this review article, the authors review the current knowledge of streptococcal toxic shock syndrome and discuss the pathophysiology as well as its supportive and specific treatment.
链球菌中毒性休克综合征是一种与A组链球菌侵袭性感染相关的严重并发症。尽管在过去几十年中，脓毒性休克患者的医疗护理取得了进展，但这种病症的死亡率仍然很高。早期识别和多学科管理是链球菌中毒性休克综合征患者护理的关键，包括对功能衰竭器官进行强化和适当的重症支持、快速诊断感染源以及手术管理。链球菌中毒性休克综合征的流行病学和危险因素仍有待深入研究，包括接触非甾体抗炎药可能的因果作用。在这篇综述文章中，作者回顾了链球菌中毒性休克综合征的现有知识，并讨论了其病理生理学以及支持性和特异性治疗。
