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妊娠恶心程度与随后创伤后应激的关系。

The association between the degree of nausea in pregnancy and subsequent posttraumatic stress.

机构信息

Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

Institute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway.

出版信息

Arch Womens Ment Health. 2019 Aug;22(4):493-501. doi: 10.1007/s00737-018-0909-z. Epub 2018 Sep 17.

Abstract

Hyperemesis gravidarum (HG) is a pregnancy condition characterised by severe nausea and vomiting during early pregnancy. The experience of HG is for many women a traumatic event. Few studies have investigated a possible association between HG and birth-related posttraumatic stress. The objective of the current study was to assess whether HG increases the risk of birth-related posttraumatic stress symptoms (PTSS). This was a population-based pregnancy cohort study using data from the Akershus Birth Cohort Study (ABC study). A linear mixed model was used to estimate the association between the degree of nausea (no nausea (n = 574), mild nausea (n = 813), severe nausea (n = 522) and HG (hospitalised due to nausea, n = 20)) and PTSS score at 8 weeks and 2 years after birth. At 8 weeks postpartum, women with HG had higher PTSS scores compared to women with no nausea (p = 0.008), women with mild nausea (p = 0.019) and women with severe nausea (p = 0.027). After 2 years, women with HG had higher PTSS scores compared to women with no nausea (p = 0.038). Women with HG had higher PTSS scores following childbirth compared to women with less pronounced symptoms or no nausea at all. After 2 years, women with HG still had higher PTSS scores compared to women with no nausea. Although the overall differences in PTSS scores were small, the results may still be of clinical relevance.

摘要

妊娠剧吐(HG)是一种妊娠疾病,其特征是在孕早期出现严重的恶心和呕吐。对许多女性来说,HG 的经历是一场创伤性事件。很少有研究调查 HG 与分娩相关创伤后应激之间的可能关联。本研究的目的是评估 HG 是否会增加与分娩相关的创伤后应激症状(PTSS)的风险。这是一项基于人群的妊娠队列研究,使用了阿克什胡斯出生队列研究(ABC 研究)的数据。使用线性混合模型来估计恶心程度(无恶心(n=574)、轻度恶心(n=813)、重度恶心(n=522)和 HG(因恶心住院,n=20))与产后 8 周和 2 年时 PTSS 评分之间的关联。产后 8 周时,与无恶心的女性(p=0.008)、轻度恶心的女性(p=0.019)和重度恶心的女性(p=0.027)相比,HG 女性的 PTSS 评分更高。2 年后,HG 女性的 PTSS 评分高于无恶心的女性(p=0.038)。与症状较轻或根本没有恶心的女性相比,HG 女性在分娩后有更高的 PTSS 评分。尽管 PTSS 评分的总体差异较小,但结果可能仍具有临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/596d/6647437/649ae3507183/737_2018_909_Fig1_HTML.jpg

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