Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
Curr Atheroscler Rep. 2018 Sep 17;20(11):55. doi: 10.1007/s11883-018-0756-4.
Tpeak-Tend interval, the time difference between the peak and the end of the T-wave, reflects the degree of dispersion of repolarization. Its prolongation has been associated with higher risks of developing ventricular arrhythmias and sudden cardiac death in different pro-arrhythmic conditions such as Brugada and long QT syndromes. In this review, we will provide a comprehensive overview on how Tpeak-Tend is altered in different atherosclerotic conditions such as hypertension, stable coronary artery disease, acute coronary obstruction, and coronary slow flow as well as inflammatory diseases affecting the arterial tree. We will explore its relationship with arterial function and dysfunction, ventricular remodeling, and arrhythmic and mortality outcomes. The published literature shows that patients with coronary atherosclerosis, whether in the form of stable coronary artery disease, chronic total occlusion, slow flow, or acute coronary obstruction, have prolonged Tpeak-Tend intervals and Tpeak-Tend/QT ratios. These can be used to predict the occurrence of ventricular arrhythmias and sudden cardiac death. They also correlate with the extent and severity of arterial stenosis and structural remodeling of the ventricles as well as arterial function and dysfunction. Finally, they can be normalized following revascularization and may therefore be used as a surrogate measure of treatment success.
T 波峰-末间期，即 T 波峰与末点之间的时间差，反映复极离散度。其延长与不同致心律失常条件下（如 Brugada 综合征和长 QT 综合征）室性心律失常和心源性猝死的风险增加相关。在这篇综述中，我们将全面介绍 T 波峰-末间期在高血压、稳定型冠状动脉疾病、急性冠状动脉阻塞和冠状动脉慢血流等不同动脉粥样硬化条件以及影响动脉树的炎症性疾病中的变化。我们将探讨其与动脉功能和功能障碍、心室重构以及心律失常和死亡率结果的关系。已发表的文献表明，患有冠状动脉粥样硬化的患者，无论是稳定型冠状动脉疾病、慢性完全闭塞、慢血流还是急性冠状动脉阻塞的形式，均有 T 波峰-末间期和 T 波峰-末/QT 比值延长。这些可用于预测室性心律失常和心源性猝死的发生。它们还与动脉狭窄的程度和严重程度以及心室的结构重构以及动脉功能和功能障碍相关。最后，它们可以在血运重建后恢复正常，因此可作为治疗成功的替代指标。
