Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart.
作者信息
Zverev A A, Anikina T A, Iskakov N G, Zefirov A L, Zefirov T L
机构信息
Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia.
Department of Normal Physiology, Kazan State Medical University of Ministry of Health of Russia, Kazan, Tatarstan Republic, Russia.
出版信息
Bull Exp Biol Med. 2018 Sep;165(5):610-612. doi: 10.1007/s10517-018-4224-5. Epub 2018 Sep 17.
We studied the effect of neuropeptide Y in concentrations of 10-10 M on electrical activity of adult rat right atrial cardiomyocytes with preserved spontaneous activity. Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10 and 10 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation. In concentration of 10 M, neuropeptide Y produced stronger effect on the analyzed parameters, while in concentration of 10 M it produced no significant changes.
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