刺激α-肾上腺素能受体对大鼠心房工作心肌细胞动作电位的影响。
Effect of Stimulation of α-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium.
作者信息
Zefirov T L, Faskhutdinov L I, Ziyatdinova N I, Galieva A M, Zefirov A L
机构信息
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia.
Department of Normal Physiology, Kazan State Medical University, Kazan, Republic of Tatarstan, Russia.
出版信息
Bull Exp Biol Med. 2019 Sep;167(5):603-605. doi: 10.1007/s10517-019-04579-w. Epub 2019 Oct 12.
The study examined the effect of clonidine hydrochloride (10-10 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10 М.
该研究考察了盐酸可乐定（10⁻¹⁰ М）对大鼠右心房工作心肌细胞电活动的影响。用可乐定刺激α-肾上腺素能受体改变了心脏的电活动。所有测试浓度的激动剂均以剂量依赖方式延长动作电位并降低心肌细胞的放电频率。在10 М浓度时观察到可乐定的最大效应。
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