Centre for Interdisciplinary Research, D. Y. Patil University, Kolhapur 416006, India.
Centre for Interdisciplinary Research, D. Y. Patil University, Kolhapur 416006, India; CÚRAM, Center for Reasearch in Medical Devices, National University of Ireland Galway, Ireland.
Int J Biol Macromol. 2019 Feb 1;122:1305-1312. doi: 10.1016/j.ijbiomac.2018.09.090. Epub 2018 Sep 15.
The hybrid chitosan-ZnO nanoparticles (C@ZnO NPs) are synthesized and coated on Silk fibroin-polyvinyl alcohol (SF-PVA) composite film by a sonochemical coating process. These are systematically studied for their synergistic antibacterial activity and reported. The coated composite films show the excellent antibacterial activity against Gram-positive and Gram-negative bacteria. The composite films are characterized by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Scanning Electron Microscopy (SEM) studies. The specific surface area and porosity are studied by Brunauer-Emmett-Teller (BET) analysis under nitrogen gas adsorption. The swelling degree, mechanical property and cell viability study of coated and uncoated composite films are investigated. The results showed that the specific surface area, porosity, swelling degree, and mechanical property of coated composite films increased with increasing the concentrations of C@ZnO NPs on SF-PVA composite film. Cell viability study confirmed the cytocompatible nature of all the C@ZnO NPs coated composite films. Thus, obtained properties of composite films reveal the potential of this material which can be used as antibacterial wound dressing applications.
壳聚糖-氧化锌纳米粒子（C@ZnO NPs）的杂化通过超声化学涂覆工艺合成并涂覆在丝素蛋白-聚乙烯醇（SF-PVA）复合膜上。对其协同抗菌活性进行了系统研究并进行了报道。涂覆的复合膜对革兰氏阳性菌和革兰氏阴性菌表现出优异的抗菌活性。通过 X 射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）研究对涂层复合膜进行了表征。在氮气吸附下通过 Brunauer-Emmett-Teller（BET）分析研究了比表面积和孔隙率。研究了涂覆和未涂覆复合膜的溶胀度、机械性能和细胞活力。结果表明，随着 SF-PVA 复合膜上 C@ZnO NPs 浓度的增加，涂层复合膜的比表面积、孔隙率、溶胀度和机械性能均增加。细胞活力研究证实了所有涂覆有 C@ZnO NPs 的复合膜的细胞相容性。因此，复合膜的这些性能表明该材料具有作为抗菌伤口敷料应用的潜力。
