一种基于吖嗪的碳硫酰胺化学传感器，用于选择性和灵敏的开-关顺序检测 Zn(II) 和 HPO ，活细胞成像和 INHIBIT 逻辑门。
An azine-based carbothioamide chemosensor for selective and sensitive turn-on-off sequential detection of Zn(II) and HPO, live cell imaging and INHIBIT logic gate.
机构信息
Department of Chemistry, Jadavpur University, Kolkata 700 032, India.
ICMR Virus Unit, Infectious Diseases & Beliaghata General Hospital, GB-4, 57, S. C. Bannerjee Road, Beliaghata, Kolkata 700 010, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jan 15;207:164-172. doi: 10.1016/j.saa.2018.09.019. Epub 2018 Sep 11.
Hydrazino-carbothioamide, 1, serves as a turn-on fluorescent chemosensor to Zn and the mixture shows green emission (λ 492) in presence of large number of ions with impressive limit of detection (LOD), 0.59 nM. Intense fluorescence of Zn-complex is selectively turn-off upon adding HPO only to the limit of detection, 26 μM, while other anions remain silent. The sensing mechanism of 1 is established by suppressing the ESIPT of 1 and complexation with Zn (CHEF) is supported by Job's plot, H NMR, and HR-MS data. Turn-on-off sequential detection of Zn and HPO also have successfully been employed for the engineering of INHIBIT molecular logic gate. The sensor is non-toxic and has been used in identifying Zn in the intracellular region of African green monkey kidney cells (Vero cells).
肼基碳硫酰胺 1 是一种对 Zn 具有开启荧光响应的化学传感器，在大量离子存在的情况下，混合物显示出绿色发射（λ 492），检测限（LOD）低至 0.59 nM。当仅向体系中加入 HPO 时，Zn 配合物的强荧光可被选择性关闭，检测限低至 26 μM，而其他阴离子则保持沉默。通过抑制 1 的 ESIPT 和与 Zn 的络合（CHEF），建立了 1 的传感机制，这一机制得到了 Job 图、1 H NMR 和 HR-MS 数据的支持。Zn 和 HPO 的开启-关闭顺序检测也成功地用于设计 INHIBIT 分子逻辑门。该传感器无毒性，并已用于鉴定非洲绿猴肾细胞（Vero 细胞）内区的 Zn。
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