Oslo University Hospital, Division of Laboratory Medicine, Department of Forensic Sciences, Norway.
Oslo University Hospital, Division of Laboratory Medicine, Department of Forensic Sciences, Norway.
Forensic Sci Int. 2018 Oct;291:e1-e3. doi: 10.1016/j.forsciint.2018.08.044. Epub 2018 Sep 6.
For the new psychoactive drug 5-(2-aminopropyl) benzofuran (5-APB), very limited knowledge is available regarding lethal concentrations. We present a case and report the post mortem blood concentration of a fatal outcome for a 25 year old man related to the consumption of 5-APB. After intake, he became unconscious and stopped breathing. Cardiopulmonary resuscitation was started without success. After 30min he was declared dead at the scene. During autopsy, whole blood from the femoral vein was collected and screened for a wide range of medicinal drugs and drugs of abuse. 5-APB was initially identified by ultra high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) and subsequently confirmed by using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The only toxicological findings were ethanol 0.6g/L, tetrahydrocannabinol (THC) 0.0024mg/L and 5-APB 0.86mg/L. The cause of death was attributed to intake of 5-APB. Only one previous report of a fatal 5-APB concentration as the main toxicological agent exist in the literature, and the present concentration indicated that 5-APB could be lethal in lower concentrations than previously reported.
对于新精神活性药物 5-(2-氨基丙基)苯并呋喃（5-APB），关于致死浓度的知识非常有限。我们报告了一个病例，并报告了与 5-APB 消耗有关的一名 25 岁男子致命后果的死后血液浓度。摄入后，他失去知觉并停止呼吸。心肺复苏术开始，但没有成功。30 分钟后，他在现场被宣布死亡。在尸检过程中，从股静脉采集全血，并对多种药物和滥用药物进行筛查。5-APB 最初通过超高效液相色谱-四极杆飞行时间质谱（UHPLC-QTOF-MS）进行鉴定，随后通过使用超高效液相色谱-串联质谱（UHPLC-MS/MS）进行确认。唯一的毒理学发现是乙醇 0.6g/L、四氢大麻酚（THC）0.0024mg/L 和 5-APB 0.86mg/L。死亡原因归因于摄入 5-APB。文献中只有一份关于致命 5-APB 浓度作为主要毒性剂的先前报告，而目前的浓度表明 5-APB 的浓度可能低于先前报告的浓度就具有致命性。
