Faculty of Medicine Lyon-Est, University of Lyon, UCBL1, Lyon, France.
Service of Forensic Medicine, Hospices Civils de Lyon, Edouard Herriot Hospital, 5 Place d'Arsonval, Lyon Cedex 03, 69437, France.
Int J Legal Med. 2024 Sep;138(5):1813-1820. doi: 10.1007/s00414-024-03236-w. Epub 2024 Apr 23.
The scientific literature contains little reliable data regarding new psychoactive substances and designer drugs, making it difficult to assess toxic blood levels and potentially lethal threshold. Here, we report a fatal co-intoxication involving two uncommon drugs ‒ alpha-methyltryptamine (AMT) and 5-(2-methylaminopropyl)-benzofuran (5-MAPB) ‒ combined with exposure to benzodiazepines, ephedrine, and norephedrine. AMT and 5-MAPB were quantified using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC/MS-MS), revealing concentrations of AMT 4690 ng/mL and 5-MAPB 101 ng/mL in postmortem peripheral blood. We additionally reviewed the literature to help interpret the likely roles of these molecules in the occurrence of death.
科学文献中关于新型精神活性物质和设计药物的可靠数据很少，因此难以评估有毒的血液水平和潜在的致死阈值。在这里，我们报告了一起涉及两种罕见药物——α-甲基色胺（AMT）和 5-（2-甲基氨基丙基）-苯并呋喃（5-MAPB）——的合并中毒致死案例，同时还接触了苯二氮䓬类、麻黄碱和去甲麻黄碱。使用超高效液相色谱-串联质谱法（UHPLC/MS-MS）对 AMT 和 5-MAPB 进行定量检测，在死后外周血中分别检测到 AMT 的浓度为 4690ng/mL 和 5-MAPB 的浓度为 101ng/mL。我们还查阅了文献，以帮助解释这些分子在死亡发生中的可能作用。
