Shenker Joel I, Singh Gurtej
Joel I. Shenker, MD, PhD, is an Associate Professor of Clinical Neurology, and Director, Neurology Residency Program at the University of Missouri - Columbia School of Medicine.
Gurtej Singh, MD, is a Neurologist with University of Missouri Health Care.
Mo Med. 2017 Jul-Aug;114(4):311-315.
Neurocognitive and sleep problems are common, underdiagnosed, and frequently co-morbid. Sleep disruption, and fatigue, predict cognitive impairment. Cognitive impairment, in turn, can worsen sleep hygiene. In dementia patients, sleep disorders are common, and dementia medications affect sleep. Emerging insights on the brain's glymphatic system suggests that sleep may drive clearance of Aβ peptide to affect Alzheimer pathophysiology. Parkinsonian dementias are linked with REM behavior disorder, a highly treatable problem that predicts future conversion into dementia.
神经认知和睡眠问题很常见，诊断不足，且常合并出现。睡眠中断和疲劳预示着认知障碍。反过来，认知障碍会恶化睡眠卫生状况。在痴呆症患者中，睡眠障碍很常见，而且治疗痴呆症的药物会影响睡眠。对大脑类淋巴系统的新见解表明，睡眠可能会促使β淀粉样肽的清除，从而影响阿尔茨海默病的病理生理过程。帕金森病性痴呆与快速眼动睡眠行为障碍有关，这是一个高度可治疗的问题，可预测未来是否会转化为痴呆症。
