Department of Urology, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Eur J Med Res. 2024 Jun 8;29(1):316. doi: 10.1186/s40001-024-01920-6.
Previous observational studies have indicated a potential link between insomnia and bladder cancer, yet the underlying causal relationship remains uncertain. The current study employed a bidirectional two-sample Mendelian randomization (MR) analysis to investigate this association.
A two-sample MR analysis was conducted utilizing publicly available summary data from genome-wide association studies (GWAS) on insomnia and bladder cancer. Various regression methods including the inverse variance weighted (IVW), weighted median, MR-Egger, weighted mode, and simple mode methods were employed for the MR analysis. The presence of pleiotropy and heterogeneity in the MR results was also assessed. Furthermore, additional sensitivity tests were performed to mitigate potential biases.
No significant causal relationship was detected between insomnia and bladder cancer using IVW method (OR = 0.761, 95% CI 0.996-1.005; P = 0.76). Similarly, the IVW model did not reveal any causal effect of bladder cancer on the risk of insomnia (OR = 1.47, 95% CI 0.772-2.799; P = 0.24). Consistent results were obtained from the other four methods employed. There was no evidence of horizontal pleiotropy or heterogeneity in our MR analysis (P > 0.05). The sensitivity analyses further supported the reliability of the estimated causal effects.
This study presents no evidence for a causal relationship between insomnia and bladder cancer.
先前的观察性研究表明，失眠与膀胱癌之间可能存在关联，但潜在的因果关系仍不确定。本研究采用双向两样本 Mendelian 随机化（MR）分析来探讨这种关联。
利用失眠和膀胱癌的全基因组关联研究（GWAS）的公开汇总数据，进行了两样本 MR 分析。采用了多种回归方法，包括逆方差加权（IVW）、加权中位数、MR-Egger、加权模式和简单模式方法，进行了 MR 分析。还评估了 MR 结果中的偏倚和异质性。此外，还进行了额外的敏感性测试以减轻潜在的偏倚。
使用 IVW 方法未发现失眠与膀胱癌之间存在显著的因果关系（OR=0.761，95%CI 0.996-1.005；P=0.76）。同样，IVW 模型也没有显示膀胱癌对失眠风险有任何因果影响（OR=1.47，95%CI 0.772-2.799；P=0.24）。其他四种方法得出的结果一致。我们的 MR 分析没有发现水平遗传异质性或异质性的证据（P>0.05）。敏感性分析进一步支持了估计因果效应的可靠性。
本研究没有证据表明失眠与膀胱癌之间存在因果关系。
